OBJECTIVE: To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor. DESIGN: Case report. SETTING: Infertility center in university hospital. PATIENT(S): An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor. INTERVENTION(S): Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program. MAIN OUTCOME MEASURE(S): Tumor markers and pregnancy result. RESULT(S): The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF. CONCLUSION(S): Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.
OBJECTIVE: To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor. DESIGN: Case report. SETTING: Infertility center in university hospital. PATIENT(S): An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor. INTERVENTION(S): Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program. MAIN OUTCOME MEASURE(S): Tumor markers and pregnancy result. RESULT(S): The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF. CONCLUSION(S): Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.
Authors: Izabela Winkler; Ilona Jaszczuk; Marek Gogacz; Piotr Szkodziak; Tomasz Paszkowski; Katarzyna Skorupska; Michał Ciebiera; Maciej Skrzypczak Journal: Int J Environ Res Public Health Date: 2022-04-20 Impact factor: 4.614
Authors: Sunita M C De Sousa; Karin S Kassahn; Liam C McIntyre; Chan-Eng Chong; Hamish S Scott; David J Torpy Journal: BMC Endocr Disord Date: 2016-11-08 Impact factor: 2.763