OBJECTIVE: To analyze rates of chromosomal anomalies in a patient with globozoospermia. DESIGN: Case report. SETTING: Tertiary-care infertility clinic. PATIENT(S): A 44-year-old man with 100% globozoospermia. INTERVENTION(S): Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): Aneuploidy rates of chromosomes 13, 16, and 21 and diploidy rate in a patient with 100% globozoospermia. RESULT(S): The aneuploidy rates in spermatozoa from a patient with globozoospermia were significantly higher than in a normospermic man. The incidence of a disomy of the chromosomes 13, 16, and 21 was 4%, 5%, and 1%, respectively, and the nullisomy rates were 2%, 2%, and 3%, respectively. CONCLUSION(S): This study demonstrates a positive correlation between globozoospermia and higher chromosomal aneuploidies of the chromosomes 13, 16, and 21, suggesting a higher risk of creating aneuploid embryos after intracytoplasmic sperm injection treatment for globozoospermia patients.
OBJECTIVE: To analyze rates of chromosomal anomalies in a patient with globozoospermia. DESIGN: Case report. SETTING: Tertiary-care infertility clinic. PATIENT(S): A 44-year-old man with 100% globozoospermia. INTERVENTION(S): Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): Aneuploidy rates of chromosomes 13, 16, and 21 and diploidy rate in a patient with 100% globozoospermia. RESULT(S): The aneuploidy rates in spermatozoa from a patient with globozoospermia were significantly higher than in a normospermic man. The incidence of a disomy of the chromosomes 13, 16, and 21 was 4%, 5%, and 1%, respectively, and the nullisomy rates were 2%, 2%, and 3%, respectively. CONCLUSION(S): This study demonstrates a positive correlation between globozoospermia and higher chromosomal aneuploidies of the chromosomes 13, 16, and 21, suggesting a higher risk of creating aneuploid embryos after intracytoplasmic sperm injection treatment for globozoospermiapatients.
Authors: F Vialard; I Hammoud; D Molina-Gomes; R Wainer; M Bergere; M Albert; M Bailly; P de Mazancourt; J Selva Journal: J Assist Reprod Genet Date: 2008-10-30 Impact factor: 3.412