OBJECTIVES: Evaluation of immunological alterations in the blood of human lindane poisoning cases. DESIGN AND METHODS: Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindane poisoning. The presence of lindane in blood was confirmed by HPLC. RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered. CONCLUSIONS: The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.
OBJECTIVES: Evaluation of immunological alterations in the blood of humanlindanepoisoning cases. DESIGN AND METHODS: Serum IgG, IgM, IgA, IgE, IL-2, IL-4, TNF-alpha, and IFN-gamma levels were measured using immunoassay in 20 human cases of lindanepoisoning. The presence of lindane in blood was confirmed by HPLC. RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Immunoglobulin levels were not altered. CONCLUSIONS: The results suggest that lindane exposure at chronically high levels affects cytokine levels in humans and indicates the severity of immunotoxicity.
Authors: Jane A Hoppin; David M Umbach; Greg J Kullman; Paul K Henneberger; Stephanie J London; Michael C R Alavanja; Dale P Sandler Journal: Occup Environ Med Date: 2006-12-20 Impact factor: 4.402