AIMS: In the face of increasing evidence of underlying genetic heterogeneity for lone atrial fibrillation (LAF), we undertook a clinical analysis of subjects to identify the phenotypic subsets of this arrhythmia. METHODS AND RESULTS: We evaluated serial patients who presented with LAF between July 5, 2001 and December 19, 2003. Subjects underwent a standardized interview to elicit a detailed medical history, prior therapies, and precipitants of atrial fibrillation. The results of a physical exam, electrocardiogram and echocardiogram were reviewed. One hundred and eighty subjects with a mean age of 45 years (15-67 years) at the time of diagnosis were enrolled. The majority of patients originally presented with paroxysmal fibrillation (94%), and 7.8% progressed to permanent AF. Reported triggers for AF included sleeping (44%), exercise (36%), alcohol use (36%), and eating (34%). Women with LAF had distinct symptoms, triggers for episodic AF, and over one-fourth had an underlying rheumatologic condition. Several subsets of AF including familial AF (39%), exercise-induced AF (32%), and conduction system disease requiring pacemaker implantation (7%), were identified. CONCLUSIONS: Family history, exercise as a trigger of AF, and a history of a pacemaker identified subtypes of LAF.
AIMS: In the face of increasing evidence of underlying genetic heterogeneity for lone atrial fibrillation (LAF), we undertook a clinical analysis of subjects to identify the phenotypic subsets of this arrhythmia. METHODS AND RESULTS: We evaluated serial patients who presented with LAF between July 5, 2001 and December 19, 2003. Subjects underwent a standardized interview to elicit a detailed medical history, prior therapies, and precipitants of atrial fibrillation. The results of a physical exam, electrocardiogram and echocardiogram were reviewed. One hundred and eighty subjects with a mean age of 45 years (15-67 years) at the time of diagnosis were enrolled. The majority of patients originally presented with paroxysmal fibrillation (94%), and 7.8% progressed to permanent AF. Reported triggers for AF included sleeping (44%), exercise (36%), alcohol use (36%), and eating (34%). Women with LAF had distinct symptoms, triggers for episodic AF, and over one-fourth had an underlying rheumatologic condition. Several subsets of AF including familial AF (39%), exercise-induced AF (32%), and conduction system disease requiring pacemaker implantation (7%), were identified. CONCLUSIONS: Family history, exercise as a trigger of AF, and a history of a pacemaker identified subtypes of LAF.
Authors: Kaylin T Nguyen; Rachel A Gladstone; Jonathan W Dukes; Babak Nazer; Eric Vittinghoff; Nitish Badhwar; Vasanth Vedantham; Edward P Gerstenfeld; Byron K Lee; Randall J Lee; Zian H Tseng; Jeffrey E Olgin; Melvin M Scheinman; Gregory M Marcus Journal: Pacing Clin Electrophysiol Date: 2016-11-10 Impact factor: 1.976
Authors: Craig T January; L Samuel Wann; Joseph S Alpert; Hugh Calkins; Joaquin E Cigarroa; Joseph C Cleveland; Jamie B Conti; Patrick T Ellinor; Michael D Ezekowitz; Michael E Field; Katherine T Murray; Ralph L Sacco; William G Stevenson; Patrick J Tchou; Cynthia M Tracy; Clyde W Yancy Journal: Circulation Date: 2014-03-28 Impact factor: 29.690
Authors: Jason D Roberts; Thomas A Dewland; David V Glidden; Thomas J Hoffmann; Dan E Arking; Lin Y Chen; Bruce M Psaty; Jeffrey E Olgin; Alvaro Alonso; Susan R Heckbert; Gregory M Marcus Journal: Am Heart J Date: 2016-02-13 Impact factor: 4.749
Authors: T Jared Bunch; Douglas L Packer; Arshad Jahangir; G Richard Locke; Nicholas J Talley; Bernard J Gersh; Ranjini R Roy; David O Hodge; Samuel J Asirvatham Journal: Am J Cardiol Date: 2008-08-27 Impact factor: 2.778
Authors: Raija Jurkko; Heikki Väänänen; Ville Mäntynen; Jouni Kuusisto; Markku Mäkijärvi; Lauri Toivonen Journal: Ann Noninvasive Electrocardiol Date: 2008-10 Impact factor: 1.468