OBJECTIVE: A door-to-door two-phase study was designed in order to estimate the prevalence of cognitive deficit amongst the residents of a district in Tuscany (central Italy). Identification of cases with mild cognitive impairment (MCI) was given high priority, because this condition has been suggested as a term for the boundary area between normal aging and dementia. METHODS: Of the 1600 subjects who completed the screening phase, 354 scored under the cut-off point of the Mini Mental State Examination and Clinical Dementia Rating and were investigated by means of a standardized diagnostic protocol. RESULTS: The prevalence of MCI and age-related cognitive decline was 4.9 and 9.3%, respectively; low levels of education significantly increased the risk of these conditions. The prevalence of dementia over age 65 was 6.2%, with a significant risk association with age. In our population, Alzheimer's disease was the most frequent type of dementia (prevalence rate 4.2%) and increased risk depending on age, sex and education has been found. CONCLUSIONS: Our findings are somewhat similar to previous studies. Further epidemiological and longitudinal studies are warranted to identify which diagnostic category is more predictive for dementia.
OBJECTIVE: A door-to-door two-phase study was designed in order to estimate the prevalence of cognitive deficit amongst the residents of a district in Tuscany (central Italy). Identification of cases with mild cognitive impairment (MCI) was given high priority, because this condition has been suggested as a term for the boundary area between normal aging and dementia. METHODS: Of the 1600 subjects who completed the screening phase, 354 scored under the cut-off point of the Mini Mental State Examination and Clinical Dementia Rating and were investigated by means of a standardized diagnostic protocol. RESULTS: The prevalence of MCI and age-related cognitive decline was 4.9 and 9.3%, respectively; low levels of education significantly increased the risk of these conditions. The prevalence of dementia over age 65 was 6.2%, with a significant risk association with age. In our population, Alzheimer's disease was the most frequent type of dementia (prevalence rate 4.2%) and increased risk depending on age, sex and education has been found. CONCLUSIONS: Our findings are somewhat similar to previous studies. Further epidemiological and longitudinal studies are warranted to identify which diagnostic category is more predictive for dementia.
Authors: F Sartucci; D Borghetti; T Bocci; L Murri; P Orsini; V Porciatti; N Origlia; L Domenici Journal: Brain Res Bull Date: 2010-04-10 Impact factor: 4.077
Authors: Jesús de Pedro-Cuesta; Javier Virués-Ortega; Saturio Vega; Manuel Seijo-Martínez; Pedro Saz; Fernanda Rodríguez; Angel Rodríguez-Laso; Ramón Reñé; Susana Pérez de las Heras; Raimundo Mateos; Pablo Martínez-Martín; José María Manubens; Ignacio Mahillo-Fernandez; Secundino López-Pousa; Antonio Lobo; Jordi Llinàs Reglà; Jordi Gascón; Francisco José García; Manuel Fernández-Martínez; Raquel Boix; Félix Bermejo-Pareja; Alberto Bergareche; Julián Benito-León; Ana de Arce; José Luis del Barrio Journal: BMC Neurol Date: 2009-10-19 Impact factor: 2.474
Authors: G A Jicha; E Abner; F A Schmitt; G E Cooper; N Stiles; R Hamon; S Carr; C D Smith; W R Markesbery Journal: Dement Geriatr Cogn Disord Date: 2008-08-23 Impact factor: 2.959
Authors: Ana Luisa Sosa; Emiliano Albanese; Blossom C M Stephan; Michael Dewey; Daisy Acosta; Cleusa P Ferri; Mariella Guerra; Yueqin Huang; K S Jacob; Ivonne Z Jiménez-Velázquez; Juan J Llibre Rodriguez; Aquiles Salas; Joseph Williams; Isaac Acosta; Maribella González-Viruet; Milagros A Guerra Hernandez; Li Shuran; Martin J Prince; Robert Stewart Journal: PLoS Med Date: 2012-02-07 Impact factor: 11.069
Authors: Miguel Angel Tola-Arribas; María Isabel Yugueros; María José Garea; Fernando Ortega-Valín; Ana Cerón-Fernández; Beatriz Fernández-Malvido; Antonio San José-Gallegos; Marta González-Touya; Ana Botrán-Velicia; Vanessa Iglesias-Rodríguez; Bárbara Díaz-Gómez Journal: PLoS One Date: 2013-10-17 Impact factor: 3.240