BACKGROUND: The left ventricular outflow tract (LVOT) malformations aortic valve stenosis (AVS), coarctation of the aorta (CoA), and hypoplastic left heart syndrome (HLHS) contribute significantly to infant mortality due to birth defects. Previous epidemiology data showed rate differences between male and female and white and black ethnic groups. The Texas Birth Defects Registry, an active surveillance program, enables study in a large, diverse population including Hispanics. METHODS: Records of children up to 1 year old with AVS, CoA, and HLHS born in Texas from 1999 to 2001, were collected from the registry. Those including additional heart defects or a chromosomal anomaly were excluded. Multivariate analysis included: infant sex; United States-Mexico border county residence; and maternal age, race/ethnicity, birthplace, and education. RESULTS: There were 910 cases among 1.08 million live births, of which 499 met inclusion criteria. Multivariate modeling of all LVOT malformations combined demonstrated lower prevalence rate ratios (PRRs) for black males (0.26) and Hispanic males (0.70). Similar results were found for CoA but not AVS or HLHS. Higher PRRs were noted for increased maternal age for LVOT (1.3 for 24-34 years; 1.7 for >34 years), AVS, and HLHS, but not CoA, and higher PRRs across all diagnoses for males (LVOT PRR, 2.4) were noted. CoA PRRs were higher in border county vs. non-border county residents (PRR, 2.1). Maternal education and birthplace were not significant factors. CONCLUSIONS: There are rate differences for males among all 3 ethnic groups. Sex and ethnic differences suggest genetic etiologies, where the ethnic differences could be used to find susceptibility loci with mapping by admixture linkage disequilibrium. Increased CoA rates along the U.S.-Mexico border suggest environmental causes that will require further monitoring. Copyright 2005 Wiley-Liss, Inc.
BACKGROUND: The left ventricular outflow tract (LVOT) malformations aortic valve stenosis (AVS), coarctation of the aorta (CoA), and hypoplastic left heart syndrome (HLHS) contribute significantly to infant mortality due to birth defects. Previous epidemiology data showed rate differences between male and female and white and black ethnic groups. The Texas Birth Defects Registry, an active surveillance program, enables study in a large, diverse population including Hispanics. METHODS: Records of children up to 1 year old with AVS, CoA, and HLHS born in Texas from 1999 to 2001, were collected from the registry. Those including additional heart defects or a chromosomal anomaly were excluded. Multivariate analysis included: infant sex; United States-Mexico border county residence; and maternal age, race/ethnicity, birthplace, and education. RESULTS: There were 910 cases among 1.08 million live births, of which 499 met inclusion criteria. Multivariate modeling of all LVOT malformations combined demonstrated lower prevalence rate ratios (PRRs) for black males (0.26) and Hispanic males (0.70). Similar results were found for CoA but not AVS or HLHS. Higher PRRs were noted for increased maternal age for LVOT (1.3 for 24-34 years; 1.7 for >34 years), AVS, and HLHS, but not CoA, and higher PRRs across all diagnoses for males (LVOT PRR, 2.4) were noted. CoA PRRs were higher in border county vs. non-border county residents (PRR, 2.1). Maternal education and birthplace were not significant factors. CONCLUSIONS: There are rate differences for males among all 3 ethnic groups. Sex and ethnic differences suggest genetic etiologies, where the ethnic differences could be used to find susceptibility loci with mapping by admixture linkage disequilibrium. Increased CoA rates along the U.S.-Mexico border suggest environmental causes that will require further monitoring. Copyright 2005 Wiley-Liss, Inc.
Authors: Kim L McBride; Susan Fernbach; Andres Menesses; Laura Molinari; Ellinor Quay; Ricardo Pignatelli; Jeffrey A Towbin; John W Belmont Journal: Birth Defects Res A Clin Mol Teratol Date: 2004-10
Authors: Mark B Lewin; Kim L McBride; Ricardo Pignatelli; Susan Fernbach; Ana Combes; Andres Menesses; Wilbur Lam; Louis I Bezold; Norman Kaplan; Jeffrey A Towbin; John W Belmont Journal: Pediatrics Date: 2004-09 Impact factor: 7.124
Authors: Stephanie LaHaye; Don Corsmeier; Madhumita Basu; Jessica L Bowman; Sara Fitzgerald-Butt; Gloria Zender; Kevin Bosse; Kim L McBride; Peter White; Vidu Garg Journal: Circ Cardiovasc Genet Date: 2016-07-14
Authors: Hisato Yagi; Xiaoqin Liu; George C Gabriel; Yijen Wu; Kevin Peterson; Stephen A Murray; Bruce J Aronow; Lisa J Martin; D Woodrow Benson; Cecilia W Lo Journal: Pediatr Cardiol Date: 2018-03-22 Impact factor: 1.655
Authors: Kim L McBride; Gloria A Zender; Sara M Fitzgerald-Butt; Nikki J Seagraves; Susan D Fernbach; Gladys Zapata; Mark Lewin; Jeffrey A Towbin; John W Belmont Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-02-02
Authors: Kim L McBride; Gloria A Zender; Sara M Fitzgerald-Butt; Daniel Koehler; Andres Menesses-Diaz; Susan Fernbach; Kwanghyuk Lee; Jeffrey A Towbin; Suzanne Leal; John W Belmont Journal: Eur J Hum Genet Date: 2009-01-14 Impact factor: 4.246
Authors: Lisa C A D'Alessandro; Petra Werner; Hongbo M Xie; Hakon Hakonarson; Peter S White; Elizabeth Goldmuntz Journal: Congenit Heart Dis Date: 2013-05-20 Impact factor: 2.007
Authors: Mark A Canfield; Cara T Mai; Ying Wang; Alissa O'Halloran; Lisa K Marengo; Richard S Olney; Christopher L Borger; Rachel Rutkowski; Jane Fornoff; Nila Irwin; Glenn Copeland; Timothy J Flood; Robert E Meyer; Russel Rickard; C J Alverson; Joseph Sweatlock; Russell S Kirby Journal: Am J Public Health Date: 2014-07-17 Impact factor: 9.308
Authors: Kim L McBride; Maurisa F Riley; Gloria A Zender; Sara M Fitzgerald-Butt; Jeffrey A Towbin; John W Belmont; Susan E Cole Journal: Hum Mol Genet Date: 2008-06-30 Impact factor: 6.150