Literature DB >> 16007501

Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels.

A Premkumar1, C R Horan, P W Gage.   

Abstract

A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 microM) and amantadine (10 microM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.

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Year:  2005        PMID： 16007501     DOI： 10.1007/s00232-005-0744-9

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  14 in total

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Authors:  M T Tosteson; L H Pinto; L J Holsinger; R A Lamb
Journal:  J Membr Biol       Date:  1994-10       Impact factor: 1.843

Review 9.  Modification of membrane permeability by animal viruses.

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Authors:  R J Sugrue; A J Hay
Journal:  Virology       Date:  1991-02       Impact factor: 3.616
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10.  Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

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