AIMS: Coronary artery calcification (CAC) is determined as a measure of the extent of coronary atherosclerosis and can be used for expanded cardiovascular risk stratification. It was our aim to establish reference CAC scores in a population-based unselected European cohort. METHODS AND RESULTS: The Heinz Nixdorf Recall study (HNR) recruited a total of 4814 participants aged 45-74 years. Cardiovascular risk factors and medications were recorded, and CAC was measured using electron-beam CT (EBCT). CAC score distribution was compared with previous studies in subjects who were self-referred, volunteered, or were physician-referred. Of the 4472 (92.9%) subjects free of clinical coronary artery disease, the CAC score was available in 4275 (95.3%) (2027 men, 2248 women). CAC scores were lower in particular in the higher age groups (> or = 60 years) in men than in the previous studies. Also, in most age groups (except the highest, 70-74 years), subjects with no cardiovascular medications had significantly lower CAC scores than subjects using cardiovascular medications. CONCLUSIONS: The current report characterises the distribution of EBCT-derived CAC scores in a European unselected population. Compared with previous reports, CAC scores were lower in our cohort, in particular in subjects not receiving cardiovascular medications. Classification of the CAC score may underestimate true risk if previously published referral cohorts are used as the reference.
AIMS: Coronary artery calcification (CAC) is determined as a measure of the extent of coronary atherosclerosis and can be used for expanded cardiovascular risk stratification. It was our aim to establish reference CAC scores in a population-based unselected European cohort. METHODS AND RESULTS: The Heinz Nixdorf Recall study (HNR) recruited a total of 4814 participants aged 45-74 years. Cardiovascular risk factors and medications were recorded, and CAC was measured using electron-beam CT (EBCT). CAC score distribution was compared with previous studies in subjects who were self-referred, volunteered, or were physician-referred. Of the 4472 (92.9%) subjects free of clinical coronary artery disease, the CAC score was available in 4275 (95.3%) (2027 men, 2248 women). CAC scores were lower in particular in the higher age groups (> or = 60 years) in men than in the previous studies. Also, in most age groups (except the highest, 70-74 years), subjects with no cardiovascular medications had significantly lower CAC scores than subjects using cardiovascular medications. CONCLUSIONS: The current report characterises the distribution of EBCT-derived CAC scores in a European unselected population. Compared with previous reports, CAC scores were lower in our cohort, in particular in subjects not receiving cardiovascular medications. Classification of the CAC score may underestimate true risk if previously published referral cohorts are used as the reference.
Authors: Joseph Yeboah; Raimund Erbel; Joseph Chris Delaney; Robin Nance; Mengye Guo; Alain G Bertoni; Matthew Budoff; Susanne Moebus; Karl-Heinz Jöckel; Gregory L Burke; Nathan D Wong; Nils Lehmann; David M Herrington; Stefan Möhlenkamp; Philip Greenland Journal: Atherosclerosis Date: 2014-08-14 Impact factor: 5.162
Authors: Kaffer Kara; Amir A Mahabadi; Marie H Geisel; Nils Lehmann; Hagen Kälsch; Marcus Bauer; Till Neumann; Nico Dragano; Susanne Moebus; Stefan Möhlenkamp; Karl-Heinz Jöckel; Raimund Erbel Journal: Clin Res Cardiol Date: 2013-10-15 Impact factor: 5.460
Authors: Simone Weyers; Nico Dragano; Susanne Möbus; Eva-Maria Beck; Andreas Stang; Stephan Möhlenkamp; Karl Heinz Jöckel; Raimund Erbel; Johannes Siegrist Journal: Int J Public Health Date: 2009-09-23 Impact factor: 3.380
Authors: H Kälsch; N Lehmann; S Möhlenkamp; T Neumann; U Slomiany; Axel Schmermund; Andreas Stang; S Moebus; M Bauer; K Mann; K-H Jöckel; R Erbel Journal: Clin Res Cardiol Date: 2010-03 Impact factor: 5.460
Authors: Marcus Bauer; Joseph A C Delaney; Stefan Möhlenkamp; Karl-Heinz Jöckel; Richard A Kronmal; Nils Lehmann; Kenneth J Mukamal; Susanne Moebus; Joseph F Polak; Nico Dragano; Matthew J Budoff; Raimund Erbel; Robyn L McClelland Journal: J Am Soc Echocardiogr Date: 2013-04-20 Impact factor: 5.251
Authors: Stefan Möhlenkamp; Nils Lehmann; Axel Schmermund; Ulla Roggenbuck; Susanne Moebus; Nico Dragano; Marcus Bauer; Hagen Kälsch; Barbara Hoffmann; Andreas Stang; Martina Bröcker-Preuss; Michael Böhm; Klaus Mann; Karl-Heinz Jöckel; Raimund Erbel Journal: Clin Res Cardiol Date: 2009-08-20 Impact factor: 5.460
Authors: Raimund Erbel; Stefan Möhlenkamp; Karl-Heinz Jöckel; Nils Lehmann; Susanne Moebus; Barbara Hoffmann; Axel Schmermund; Andreas Stang; Johannes Siegrist; Nico Dragano; Dietrich Grönemeyer; Rainer Seibel; Klaus Mann; Martina Bröcker-Preuss; Knut Kröger; Lothar Volbracht Journal: Dtsch Arztebl Int Date: 2008-01-07 Impact factor: 5.594