| Literature DB >> 16005144 |
Anu Voho1, Katja Metsola, Sisko Anttila, Olli Impivaara, Jorma Järvisalo, Harri Vainio, Kirsti Husgafvel-Pursiainen, Ari Hirvonen.
Abstract
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105). The controls were distributed into five age strata, which enabled us to examine the potential age-related changes in the putative EPHX1 at-risk genotypes in the cancer free population. Although the exon 3 slow activity associated allele (His113) containing genotypes posed a decreased lung cancer risk compared with the homozygous wild-type Tyr113/Tyr113 genotype (OR, 0.68; 95% CI, 0.49-0.94), no association was seen for the EPHX1 phenotypes interpreted from the combined exons 3 and 4 genotype data. Neither was any difference seen in the prevalence of the EPHX1 Tyr113His genotypes or interpreted EPHX1 phenotypes in the different age groups.Entities:
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Year: 2005 PMID： 16005144 DOI： 10.1016/j.canlet.2005.05.029
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679