| Literature DB >> 16004935 |
Seiji Onogawa1, Yasuhiko Kitadai, Toru Amioka, Michiyo Kodama, Songde Cho, Tsuyoshi Kuroda, Takehiko Ochiumi, Shigeru Kimura, Toshio Kuwai, Shinji Tanaka, Kazuaki Chayama.
Abstract
In this study, we investigated whether expression of vascular endothelial growth factor (VEGF)-C and/or VEGF-D correlates with clinicopathological features of human gastric carcinoma. We immunohistochemically examined the expression of VEGF-C and VEGF-D in 140 archival surgical specimens of submucosally invasive gastric carcinoma. Of these specimens, 32 (22.9%) and 12 (8.6%) showed intense VEGF-C and VEGF-D immunoreactivity in cancer cells, respectively. VEGF-C immunoreactivity was associated with histological type, lymphatic invasion, lymph node metastasis, and microvessel density. No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma.Entities:
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Year: 2005 PMID： 16004935 DOI： 10.1016/j.canlet.2004.12.030
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679