OBJECTIVE: To determine if creatine monohydrate supplementation can improve body composition and enhance recoveryafter total knee arthroplasty (TKA). DESIGN: Randomized trial in which creatine monohydrate or placebo was administered. SETTING: Public primary care facility. PARTICIPANTS: Thirty-seven adults (17 men, 20 women) with osteoarthritis undergoing TKA. Intervention Subjects received creatine monohydrate (10 g/d x 10 d presurgery to 5 g/d x 30 d postsurgery) or placebo. MAIN OUTCOME MEASURES: Body composition (dual-energy x-ray absorptiometry scanning), muscle metabolite concentrations (adenosine triphosphate, phosphocreatine, creatine, total creatine [phosphocreatine + creatine]), muscle histomorphometery, quadriceps, ankle dorsiflexion and handgrip strength, and functional capacity. All measurements were completed preoperatively (-7 d) and 30 days postoperatively, except for that of muscle metabolites. Muscle metabolite samples were collected during surgery (0 d) and at 30 days. RESULTS: A significant decrease in quadriceps and ankle dorsiflexion strength was observed at 30 days postoperatively (P < .01). There were no significant effects of creatine monohydrate supplementation on any of the measured outcome variables. CONCLUSIONS:Creatine monohydrate supplementation did not improve body composition or muscle strength when given before surgery, nor did it enhance recovery after TKA.
RCT Entities:
OBJECTIVE: To determine if creatine monohydrate supplementation can improve body composition and enhance recovery after total knee arthroplasty (TKA). DESIGN: Randomized trial in which creatine monohydrate or placebo was administered. SETTING: Public primary care facility. PARTICIPANTS: Thirty-seven adults (17 men, 20 women) with osteoarthritis undergoing TKA. Intervention Subjects received creatine monohydrate (10 g/d x 10 d presurgery to 5 g/d x 30 d postsurgery) or placebo. MAIN OUTCOME MEASURES: Body composition (dual-energy x-ray absorptiometry scanning), muscle metabolite concentrations (adenosine triphosphate, phosphocreatine, creatine, total creatine [phosphocreatine + creatine]), muscle histomorphometery, quadriceps, ankle dorsiflexion and handgrip strength, and functional capacity. All measurements were completed preoperatively (-7 d) and 30 days postoperatively, except for that of muscle metabolites. Muscle metabolite samples were collected during surgery (0 d) and at 30 days. RESULTS: A significant decrease in quadriceps and ankle dorsiflexion strength was observed at 30 days postoperatively (P < .01). There were no significant effects of creatine monohydrate supplementation on any of the measured outcome variables. CONCLUSIONS:Creatine monohydrate supplementation did not improve body composition or muscle strength when given before surgery, nor did it enhance recovery after TKA.
Authors: James M Gwinnutt; Maud Wieczorek; Javier Rodríguez-Carrio; Andra Balanescu; Heike A Bischoff-Ferrari; Annelies Boonen; Giulio Cavalli; Savia de Souza; Annette de Thurah; Thomas E Dorner; Rikke Helene Moe; Polina Putrik; Lucía Silva-Fernández; Tanja Stamm; Karen Walker-Bone; Joep Welling; Mirjana Zlatković-Švenda; Francis Guillemin; Suzanne M M Verstappen Journal: RMD Open Date: 2022-06
Authors: Benjamin Wax; Chad M Kerksick; Andrew R Jagim; Jerry J Mayo; Brian C Lyons; Richard B Kreider Journal: Nutrients Date: 2021-06-02 Impact factor: 5.717
Authors: Kylie K Harmon; Jeffrey R Stout; David H Fukuda; Patrick S Pabian; Eric S Rawson; Matt S Stock Journal: Nutrients Date: 2021-05-27 Impact factor: 5.717