| Literature DB >> 16002291 |
Anne-Claude Dublanchet1, Pierre Ducrot, Charles Andrianjara, Margaret O'Gara, Renaud Morales, Delphine Compère, Alexis Denis, Stéphane Blais, Philippe Cluzeau, Karine Courté, Jacques Hamon, François Moreau, Marie-Laure Prunet, Anita Tertre.
Abstract
A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.Entities:
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Year: 2005 PMID： 16002291 DOI： 10.1016/j.bmcl.2005.05.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823