| Literature DB >> 16002288 |
Kai Long1, Michael Boyce, He Lin, Junying Yuan, Dawei Ma.
Abstract
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.Entities:
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Year: 2005 PMID： 16002288 DOI： 10.1016/j.bmcl.2005.05.120
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823