| Literature DB >> 16002282 |
Minerva A Hughes1, Jill M McFadden, Craig A Townsend.
Abstract
The synthesis and antimycobacterial activity of a series of alpha-methylene-gamma-butyrolactones based on the natural product protolichesterinic acid are described. Compounds 9-12 bearing an allylamide group at the C-4 position showed improved activity with MICs in the range of 6.25-12.5 microg/mL.Entities:
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Year: 2005 PMID： 16002282 DOI： 10.1016/j.bmcl.2005.05.119
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823