| Literature DB >> 16002173 |
Gottfried Mayer1, Vitali Vogel, Jörg Weyermann, Dirk Lochmann, Jacomina A van den Broek, Christos Tziatzios, Winfried Haase, Daan Wouters, Ulrich S Schubert, Andreas Zimmer, Jörg Kreuter, Dieter Schubert.
Abstract
Nanoparticles prepared by self-assembly from oligonucleotides (ONs), protamine free base, and human serum albumin ("ternary proticles") are spheres of diameters around 200 nm. Substitution of the protamine free base by protamine sulfate leads to proticles of only around 40 nm in diameter with otherwise unchanged properties. The availability of drug delivery systems of very similar composition but grossly different size may be advantageous when dealing with cells which show size-dependent particle uptake. These nanoparticles are promising candidates for ON delivery to cells because of the following reasons: (1) They are stable for several hours in solutions of up to physiological ionic strength; (2) they are efficiently taken up by cells; (3) after cellular uptake, they easily release the ONs even when these are present as phosphorothioates.Entities:
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Year: 2005 PMID： 16002173 DOI： 10.1016/j.jconrel.2005.04.019
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776