Literature DB >> 16002031

Alcohol and benzodiazepines in falls: an epidemiological view.

Ilsemarie Kurzthaler1, Markus Wambacher, Karl Golser, Gernot Sperner, Barbara Sperner-Unterweger, Alexander Haidekker, Marion Pavlic, Georg Kemmler, W Wolfgang Fleischhacker.   

Abstract

Falls are common at all ages and especially in the elderly; it is important to understand contributing causes. Over a 1-year period we studied blood alcohol (BAC) and benzodiazepine concentrations in patients attending an emergency department because of a fall. The 22% of 615 patients tested were positive for alcohol, 55% were positive for benzodiazepines (BZD) and 1.5% were positive for both substances. A significantly larger proportion of males tested positive for alcohol (40.2%) than females (7.6%). Both in males and females the percentage as well as the extent of blood alcohol levels decreased significantly with age. Benzodiazepines were also consumed more frequently in males (8.5%) than in females (3.2%, p=0.007). Concerning BAC there was no difference between males (1.75+/-0.81 g/l) and females (1.66+/-0.91 g/l). In patients older than 70 years the BAC (1.30+/-0.80 g/l) was lower in comparison to younger ones. All blood samples positive for benzodiazepines could be traced back to diazepam consumption. We found a high number of young and middle aged patients using alcohol (males=49.7%; females=18.9%) and a lower but still relevant number of benzodiazepine users (males=9.5%; females=2.4%). In addition, this study shows that alcohol plays a more important role in patients up to 70 years in fall-related accidents when compared to accidents of other causes.

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Year:  2005        PMID: 16002031     DOI: 10.1016/j.drugalcdep.2005.01.012

Source DB:  PubMed          Journal:  Drug Alcohol Depend        ISSN: 0376-8716            Impact factor:   4.492


  6 in total

Review 1.  Medication-related falls in the elderly: causative factors and preventive strategies.

Authors:  Allen R Huang; Louise Mallet; Christian M Rochefort; Tewodros Eguale; David L Buckeridge; Robyn Tamblyn
Journal:  Drugs Aging       Date:  2012-05-01       Impact factor: 3.923

Review 2.  Characterizing the Interrelationships of Prescription Opioid and Benzodiazepine Drugs With Worker Health and Workplace Hazards.

Authors:  Michele Kowalski-McGraw; Judith Green-McKenzie; Sudha P Pandalai; Paul A Schulte
Journal:  J Occup Environ Med       Date:  2017-11       Impact factor: 2.162

3.  Effect of alcohol coadministration on the pharmacodynamics, pharmacokinetics, and safety of lemborexant: A randomized, placebo-controlled crossover study.

Authors:  Ishani Landry; Nancy Hall; Jagadeesh Aluri; Gleb Filippov; Beatrice Setnik; Satish Dayal; Larisa Reyderman; Margaret Moline
Journal:  J Psychopharmacol       Date:  2022-06       Impact factor: 4.562

4.  Pharmacological Interactions between the Dual Orexin Receptor Antagonist Daridorexant and Ethanol in a Double-Blind, Randomized, Placebo-Controlled, Double-Dummy, Four-Way Crossover Phase I Study in Healthy Subjects.

Authors:  Benjamin Berger; Sander Brooks; Rob Zuiker; Muriel Richard; Clemens Muehlan; Jasper Dingemanse
Journal:  CNS Drugs       Date:  2020-11-18       Impact factor: 5.749

5.  The prevalence of potential alcohol-drug interactions in older adults.

Authors:  Sirpa Immonen; Jaakko Valvanne; Kaisu H Pitkälä
Journal:  Scand J Prim Health Care       Date:  2013-04-29       Impact factor: 2.581

6.  Acute facial trauma in falling accidents: MDCT analysis of 500 patients.

Authors:  Elina M Salonen; Mika P Koivikko; Seppo K Koskinen
Journal:  Emerg Radiol       Date:  2008-05-15
  6 in total

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