Literature DB >> 16000504

Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation.

Sebastian Voigt1, Detlef Michel, Olivia Kershaw, Jörn-Sven Kühl, Thomas Mertens, Wolfram Ebell, Helga Meisel.   

Abstract

Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.

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Year:  2005        PMID： 16000504      PMCID： PMC1169106          DOI： 10.1128/JCM.43.7.3551-3554.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  14 in total

Review 1.  Antiviral drug resistance in human cytomegalovirus.

Authors:  S Chou
Journal:  Transpl Infect Dis       Date:  1999-06       Impact factor: 2.228

2.  Immunotherapy of cytomegalovirus infection after stem-cell transplantation: a new option?

Authors:  Hermann Einsele; Klaus Hamprecht
Journal:  Lancet       Date:  2003-10-25       Impact factor: 79.321

3.  Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.

Authors:  Sunwen Chou; Rachel H Waldemer; Anne E Senters; Kevin S Michels; George W Kemble; Richard C Miner; W Lawrence Drew
Journal:  J Infect Dis       Date:  2001-12-17       Impact factor: 5.226

4.  Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system.

Authors:  Fausto Baldanti; Detlef Michel; Lavinia Simoncini; Maria Heuschmid; Albert Zimmermann; Rosalba Minisini; Peter Schaarschmidt; Thomas Schmid; Giuseppe Gerna; Thomas Mertens
Journal:  Antiviral Res       Date:  2002-04       Impact factor: 5.970

Review 5.  Resistance of human cytomegalovirus to antiviral drugs.

Authors:  A Erice
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

6.  Aciclovir selects for ganciclovir-cross-resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein.

Authors:  D Michel; S Höhn; T Haller; D Jun; T Mertens
Journal:  J Med Virol       Date:  2001-09       Impact factor: 2.327

7.  Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation.

Authors:  F Crippa; L Corey; E L Chuang; G Sale; M Boeckh
Journal:  Clin Infect Dis       Date:  2001-01-15       Impact factor: 9.079

8.  CMV retinitis after allogeneic bone marrow transplantation: a report of five cases.

Authors:  Kajsa Larsson; B Lönnqvist; O Ringdén; B Hedquist; P Ljungman
Journal:  Transpl Infect Dis       Date:  2002-06       Impact factor: 2.228

9.  Emergence of drug-resistant cytomegalovirus retinitis in the contralateral eyes of patients with AIDS treated with ganciclovir.

Authors:  Yumi Imai; Carol Shum; Daniel F Martin; Baruch D Kuppermann; W Lawrence Drew; Todd P Margolis
Journal:  J Infect Dis       Date:  2004-01-28       Impact factor: 5.226

10.  Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain.

Authors:  Klaus Hamprecht; Tobias Eckle; Lothar Prix; Christoph Faul; Hermann Einsele; Gerhard Jahn
Journal:  J Infect Dis       Date:  2002-12-13       Impact factor: 5.226
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  4 in total

1.  Improved detection of mutated human cytomegalovirus UL97 by pyrosequencing.

Authors:  Birgit Schindele; Luise Apelt; Jörg Hofmann; Andreas Nitsche; Detlef Michel; Sebastian Voigt; Thomas Mertens; Bernhard Ehlers
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

2.  Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.

Authors:  Katja Spiess; Mads G Jeppesen; Mikkel Malmgaard-Clausen; Karen Krzywkowski; Kalpana Dulal; Tong Cheng; Gertrud M Hjortø; Olav Larsen; John S Burg; Michael A Jarvis; K Christopher Garcia; Hua Zhu; Thomas N Kledal; Mette M Rosenkilde
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-15       Impact factor: 11.205

3.  Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient.

Authors:  Katharina Göhring; Tobias Feuchtinger; Elfriede Mikeler; Peter Lang; Gerhard Jahn; Rupert Handgretinger; Klaus Hamprecht
Journal:  J Mol Diagn       Date:  2009-05-28       Impact factor: 5.568

4.  Bilateral cytomegalovirus retinitis in a healthy infant.

Authors:  Seyedeh Maryam Hosseini; Mir-Naghi Moosavi; Naser Shoeibi; Mehdi Sakhaee; Hossein Ghavamsaeedi
Journal:  J Curr Ophthalmol       Date:  2016-12-23
  4 in total

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