Literature DB >> 16000317

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

A J Myers1, M Kaleem, L Marlowe, A M Pittman, A J Lees, H C Fung, J Duckworth, D Leung, A Gibson, C M Morris, R de Silva, J Hardy.   

Abstract

Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16000317     DOI： 10.1093/hmg/ddi241

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  81 in total

1.  An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.

Authors:  Christian Wider; Owen A Ross; Kenya Nishioka; Michael G Heckman; Carles Vilariño-Güell; Barbara Jasinska-Myga; Nilufer Erketin-Taner; Rosa Rademakers; Neill R Graff-Radford; Deborah C Mash; Spiridon Papapetropoulos; Ranjan Duara; Hirotake Uchikado; Zbigniew K Wszolek; Matthew J Farrer; Dennis W Dickson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2012-01-30       Impact factor: 10.154

2.  An integrative systems-based analysis of substance use: eQTL-informed gene-based tests, gene networks, and biological mechanisms.

Authors:  Zachary F Gerring; Angela Mina Vargas; Eric R Gamazon; Eske M Derks
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2020-12-23       Impact factor: 3.568

3.  Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.

Authors:  Miao Yang; Hao Tan; Qiaoling Yang; Feng Wang; Huiling Yao; Qingyi Wei; Robert M Tanguay; Tangchun Wu
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

4.  Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease.

Authors:  Michael G Heckman; Koji Kasanuki; Rebecca R Brennan; Catherine Labbé; Emily R Vargas; Alexandra I Soto; Melissa E Murray; Shunsuke Koga; Dennis W Dickson; Owen A Ross
Journal:  Mov Disord       Date:  2019-06-24       Impact factor: 10.338

Review 5.  Knock-out and transgenic mouse models of tauopathies.

Authors:  Franziska Denk; Richard Wade-Martins
Journal:  Neurobiol Aging       Date:  2007-06-22       Impact factor: 4.673

6.  Split DNA enzyme for visual single nucleotide polymorphism typing.

Authors:  Dmitry M Kolpashchikov
Journal:  J Am Chem Soc       Date:  2008-02-19       Impact factor: 15.419

7.  Differential incorporation of tau isoforms in Alzheimer's disease.

Authors:  Marisol Espinoza; Rohan de Silva; Dennis W Dickson; Peter Davies
Journal:  J Alzheimers Dis       Date:  2008-05       Impact factor: 4.472

8.  Tau as a biomarker of neurodegenerative diseases.

Authors:  Susanna Schraen-Maschke; Nicolas Sergeant; Claire-Marie Dhaenens; Stéphanie Bombois; Vincent Deramecourt; Marie-Laure Caillet-Boudin; Florence Pasquier; Claude-Alain Maurage; Bernard Sablonnière; Eugeen Vanmechelen; Luc Buée
Journal:  Biomark Med       Date:  2008-08       Impact factor: 2.851

Review 9.  Alzheimer's disease pathologic cascades: who comes first, what drives what.

Authors:  Russell H Swerdlow
Journal:  Neurotox Res       Date:  2011-09-13       Impact factor: 3.911

Review 10.  Transgenic Drosophila models of Alzheimer's disease and tauopathies.

Authors:  Kanae Iijima-Ando; Koichi Iijima
Journal:  Brain Struct Funct       Date:  2009-12-05       Impact factor: 3.270
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.