| Literature DB >> 15999989 |
Mike Barker1, Margaret Clackers, Derek A Demaine, Davina Humphreys, Michael J Johnston, Haydn T Jones, Francois Pacquet, John M Pritchard, Mark Salter, Stephen E Shanahan, Philip A Skone, Victoria M Vinader, Iain Uings, Iain M McLay, Simon J F Macdonald.
Abstract
Structurally related glucocorticoid receptor (GR) binders were docked into the GR active site to select the binding mode closest to the true docking mode. This process, termed an "agreement docking method", led to the design of tetrahydronaphthalene 9. The method was validated by the syntheses of 9 and related analogues, which are potent binders of GR. 15a is a partial agonist while 9e and 15a are micromolar antagonists in a mouse mammary tumor virus transactivation assay.Entities:
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Year: 2005 PMID： 15999989 DOI： 10.1021/jm050345y
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446