| Literature DB >> 15999988 |
Alexis D C Parenty1, Louise V Smith, Kevin M Guthrie, De-Liang Long, Jane Plumb, Robert Brown, Leroy Cronin.
Abstract
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.Entities:
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Year: 2005 PMID： 15999988 DOI： 10.1021/jm050320z
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446