Literature DB >> 15999534

Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells.

Jing-Yuan Chuang1, Yueh-Yu Tsai, Ssu-Ching Chen, Tian-Jye Hsieh, Jing-Gung Chung.   

Abstract

The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G0/G1-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.

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Year:  2005        PMID： 15999534

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  5 in total

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4.  Oleanolic acid derivatives induce apoptosis in human leukemia K562 cell involved in inhibition of both Akt1 translocation and pAkt1 expression.

Authors:  Shuhua Pan; Jun Hu; Tingting Zheng; Xinyuan Liu; Yong Ju; Chuanlian Xu
Journal:  Cytotechnology       Date:  2014-04-12       Impact factor: 2.058

5.  DCLK1 Inhibition Sensitizes Colorectal Cancer Cells to Radiation Treatment.

Authors:  Chiman Mohammadi; Ali Mahdavinezhad; Massoud Saidijam; Fatemeh Bahreini; Abdolazim Sedighi Pashaki; Mohammad Hadi Gholami; Rezvan Najafi
Journal:  Int J Mol Cell Med       Date:  2021-05-22
  5 in total

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