Literature DB >> 15998821

Functional abdominal pain.

P J Matthews1, Q Aziz.   

Abstract

Functional abdominal pain or functional abdominal pain syndrome (FAPS) is an uncommon functional gut disorder characterised by chronic or recurrent abdominal pain attributed to the gut but poorly related to gut function. It is associated with abnormal illness behaviour and patients show psychological morbidity that is often minimised or denied in an attempt to discover an organic cause for symptoms. Thus the conventional biomedical approach to the management of such patients is unhelpful and a person's symptom experience is more usefully investigated using a biopsychosocial evaluation, which necessarily entails a multidisciplinary system of healthcare provision. Currently the pathophysiology of the disorder is poorly understood but is most likely to involve a dysfunction of central pain mechanisms either in terms of attentional bias, for example, hypervigilance or a failure of central pain modulation/inhibition. Although modern neurophysiological investigation of patients is promising and may provide important insights into the pathophysiology of FAPS, current clinical management relies on an effective physician-patient relationship in which limits on clinical investigation are set and achievable treatment goals tailored to the patient's needs are pursued.

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Year:  2005        PMID: 15998821      PMCID: PMC1743310          DOI: 10.1136/pgmj.2004.030577

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN: 0032-5473            Impact factor:   2.401


  54 in total

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Authors:  J Sawynok; M J Esser; A R Reid
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Review 2.  Functional neuroimaging of visceral sensation.

Authors:  Q Aziz; A Schnitzler; P Enck
Journal:  J Clin Neurophysiol       Date:  2000-11       Impact factor: 2.177

3.  Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

Authors:  H H Chuang ; E D Prescott; H Kong; S Shields; S E Jordt; A I Basbaum; M V Chao; D Julius
Journal:  Nature       Date:  2001-06-21       Impact factor: 49.962

Review 4.  Review article: an integrated approach to the irritable bowel syndrome.

Authors:  D A Drossman
Journal:  Aliment Pharmacol Ther       Date:  1999-05       Impact factor: 8.171

5.  ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease.

Authors:  Y Yiangou; P Facer; P A Baecker; A P Ford; C H Knowles; C L Chan; N S Williams; P Anand
Journal:  Neurogastroenterol Motil       Date:  2001-08       Impact factor: 3.598

6.  Interleukin-1beta sensitizes abdominal visceral afferents of cats to ischaemia and histamine.

Authors:  L W Fu; J C Longhurst
Journal:  J Physiol       Date:  1999-11-15       Impact factor: 5.182

7.  Increased acid-sensing ion channel ASIC-3 in inflamed human intestine.

Authors:  Y Yiangou; P Facer; J A Smith; L Sangameswaran; R Eglen; R Birch; C Knowles; N Williams; P Anand
Journal:  Eur J Gastroenterol Hepatol       Date:  2001-08       Impact factor: 2.566

Review 8.  Neuronal plasticity: increasing the gain in pain.

Authors:  C J Woolf; M W Salter
Journal:  Science       Date:  2000-06-09       Impact factor: 47.728

9.  Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome.

Authors:  R C Spiller; D Jenkins; J P Thornley; J M Hebden; T Wright; M Skinner; K R Neal
Journal:  Gut       Date:  2000-12       Impact factor: 23.059

10.  Vanilloid receptor 1 immunoreactivity in inflamed human bowel.

Authors:  Y Yiangou; P Facer; N H Dyer; C L Chan; C Knowles; N S Williams; P Anand
Journal:  Lancet       Date:  2001-04-28       Impact factor: 79.321

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  3 in total

1.  Functional abdominal pain.

Authors:  Madhusudan Grover; Douglas A Drossman
Journal:  Curr Gastroenterol Rep       Date:  2010-10

2.  Quantitative Assessment of Secondary Healthcare Utilisation by Patients With Functional Abdominal Pain.

Authors:  Emma MacVicar; Pauline Insch; Fiona Summers; Duff Bruce; George Ramsay
Journal:  Cureus       Date:  2022-05-19

Review 3.  Mechanisms and management of functional abdominal pain.

Authors:  Adam D Farmer; Qasim Aziz
Journal:  J R Soc Med       Date:  2014-09       Impact factor: 5.344

  3 in total

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