Literature DB >> 15998714

Transcriptional compensation for gene loss plays a minor role in maintaining genetic robustness in Saccharomyces cerevisiae.

Sharyl L Wong1, Frederick P Roth.   

Abstract

If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples; however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintaining genetic robustness.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15998714      PMCID： PMC1456790          DOI： 10.1534/genetics.105.046060

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  18 in total

1.  Widespread aneuploidy revealed by DNA microarray expression profiling.

Authors:  T R Hughes; C J Roberts; H Dai; A R Jones; M R Meyer; D Slade; J Burchard; S Dow; T R Ward; M J Kidd; S H Friend; M J Marton
Journal:  Nat Genet       Date:  2000-07       Impact factor: 38.330

2.  Functional discovery via a compendium of expression profiles.

Authors:  T R Hughes; M J Marton; A R Jones; C J Roberts; R Stoughton; C D Armour; H A Bennett; E Coffey; H Dai; Y D He; M J Kidd; A M King; M R Meyer; D Slade; P Y Lum; S B Stepaniants; D D Shoemaker; D Gachotte; K Chakraburtty; J Simon; M Bard; S H Friend
Journal:  Cell       Date:  2000-07-07       Impact factor: 41.582

3.  Robustness against mutations in genetic networks of yeast.

Authors:  A Wagner
Journal:  Nat Genet       Date:  2000-04       Impact factor: 38.330

4.  Systematic genetic analysis with ordered arrays of yeast deletion mutants.

Authors:  A H Tong; M Evangelista; A B Parsons; H Xu; G D Bader; N Pagé; M Robinson; S Raghibizadeh; C W Hogue; H Bussey; B Andrews; M Tyers; C Boone
Journal:  Science       Date:  2001-12-14       Impact factor: 47.728

5.  Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

Authors:  E A Winzeler; D D Shoemaker; A Astromoff; H Liang; K Anderson; B Andre; R Bangham; R Benito; J D Boeke; H Bussey; A M Chu; C Connelly; K Davis; F Dietrich; S W Dow; M El Bakkoury; F Foury; S H Friend; E Gentalen; G Giaever; J H Hegemann; T Jones; M Laub; H Liao; N Liebundguth; D J Lockhart; A Lucau-Danila; M Lussier; N M'Rabet; P Menard; M Mittmann; C Pai; C Rebischung; J L Revuelta; L Riles; C J Roberts; P Ross-MacDonald; B Scherens; M Snyder; S Sookhai-Mahadeo; R K Storms; S Véronneau; M Voet; G Volckaert; T R Ward; R Wysocki; G S Yen; K Yu; K Zimmermann; P Philippsen; M Johnston; R W Davis
Journal:  Science       Date:  1999-08-06       Impact factor: 47.728

6.  Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae.

Authors:  H Terashima; N Yabuki; M Arisawa; K Hamada; K Kitada
Journal:  Mol Gen Genet       Date:  2000-09

7.  Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.

Authors:  T R Hughes; M Mao; A R Jones; J Burchard; M J Marton; K W Shannon; S M Lefkowitz; M Ziman; J M Schelter; M R Meyer; S Kobayashi; C Davis; H Dai; Y D He; S B Stephaniants; G Cavet; W L Walker; A West; E Coffey; D D Shoemaker; R Stoughton; A P Blanchard; S H Friend; P S Linsley
Journal:  Nat Biotechnol       Date:  2001-04       Impact factor: 54.908

8.  Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae.

Authors:  Arnaud Lagorce; Nicole C Hauser; Delphine Labourdette; Cristina Rodriguez; Helene Martin-Yken; Javier Arroyo; Jörg D Hoheisel; Jean François
Journal:  J Biol Chem       Date:  2003-03-18       Impact factor: 5.157

9.  Functional profiling of the Saccharomyces cerevisiae genome.

Authors:  Guri Giaever; Angela M Chu; Li Ni; Carla Connelly; Linda Riles; Steeve Véronneau; Sally Dow; Ankuta Lucau-Danila; Keith Anderson; Bruno André; Adam P Arkin; Anna Astromoff; Mohamed El-Bakkoury; Rhonda Bangham; Rocio Benito; Sophie Brachat; Stefano Campanaro; Matt Curtiss; Karen Davis; Adam Deutschbauer; Karl-Dieter Entian; Patrick Flaherty; Francoise Foury; David J Garfinkel; Mark Gerstein; Deanna Gotte; Ulrich Güldener; Johannes H Hegemann; Svenja Hempel; Zelek Herman; Daniel F Jaramillo; Diane E Kelly; Steven L Kelly; Peter Kötter; Darlene LaBonte; David C Lamb; Ning Lan; Hong Liang; Hong Liao; Lucy Liu; Chuanyun Luo; Marc Lussier; Rong Mao; Patrice Menard; Siew Loon Ooi; Jose L Revuelta; Christopher J Roberts; Matthias Rose; Petra Ross-Macdonald; Bart Scherens; Greg Schimmack; Brenda Shafer; Daniel D Shoemaker; Sharon Sookhai-Mahadeo; Reginald K Storms; Jeffrey N Strathern; Giorgio Valle; Marleen Voet; Guido Volckaert; Ching-yun Wang; Teresa R Ward; Julie Wilhelmy; Elizabeth A Winzeler; Yonghong Yang; Grace Yen; Elaine Youngman; Kexin Yu; Howard Bussey; Jef D Boeke; Michael Snyder; Peter Philippsen; Ronald W Davis; Mark Johnston
Journal:  Nature       Date:  2002-07-25       Impact factor: 49.962

10.  Role of duplicate genes in genetic robustness against null mutations.

Authors:  Zhenglong Gu; Lars M Steinmetz; Xun Gu; Curt Scharfe; Ronald W Davis; Wen-Hsiung Li
Journal:  Nature       Date:  2003-01-02       Impact factor: 49.962
View more
  9 in total

1.  Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon?

Authors:  Xionglei He; Jianzhi Zhang
Journal:  Genetics       Date:  2005-12-01       Impact factor: 4.562

2.  Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells.

Authors:  Sun H Peck; Irwin Chen; David R Liu
Journal:  Chem Biol       Date:  2011-05-27

3.  WebPARE: web-computing for inferring genetic or transcriptional interactions.

Authors:  Cheng-Long Chuang; Jia-Hong Wu; Chi-Sheng Cheng; Grace S Shieh
Journal:  Bioinformatics       Date:  2009-12-10       Impact factor: 6.937

4.  Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.

Authors:  Jan Ihmels; Sean R Collins; Maya Schuldiner; Nevan J Krogan; Jonathan S Weissman
Journal:  Mol Syst Biol       Date:  2007-03-27       Impact factor: 11.429

5.  Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus.

Authors:  Adrián Gonzalo; Marie-Odile Lucas; Catherine Charpentier; Greta Sandmann; Andrew Lloyd; Eric Jenczewski
Journal:  Nat Commun       Date:  2019-05-29       Impact factor: 14.919

6.  Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations.

Authors:  Károly Kovács; Zoltán Farkas; Djordje Bajić; Dorottya Kalapis; Andreea Daraba; Karola Almási; Bálint Kintses; Zoltán Bódi; Richard A Notebaart; Juan F Poyatos; Patrick Kemmeren; Frank C P Holstege; Csaba Pál; Balázs Papp
Journal:  Mol Biol Evol       Date:  2021-03-09       Impact factor: 16.240

7.  Feature Identification of Compensatory Gene Pairs without Sequence Homology in Yeast.

Authors:  Chien-Hua Peng; Shu-Hsi Lin; Shih-Chi Peng; Ping-Chiang Lyu; Masanori Arita; Chuan-Yi Tang
Journal:  Comp Funct Genomics       Date:  2012-08-16

8.  Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis.

Authors:  Getachew Tesfaye Beyene; Shewit Kalayou; Tahira Riaz; Tone Tonjum
Journal:  BMC Microbiol       Date:  2017-04-21       Impact factor: 3.605

9.  Dissecting the Fitness Costs of Complex Mutations.

Authors:  Pablo Yubero; Juan F Poyatos
Journal:  Mol Biol Evol       Date:  2021-09-27       Impact factor: 16.240
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.