Literature DB >> 15997158

Concise synthesis of dl-febrifugine.

Yasuo Takeuchi1, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama.   

Abstract

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an omega-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

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Year:  2005        PMID： 15997158     DOI： 10.1248/cpb.53.868

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  1 in total

1.  The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Authors:  Jonathan D Herman; Lauren R Pepper; Joseph F Cortese; Guillermina Estiu; Kevin Galinsky; Vanessa Zuzarte-Luis; Emily R Derbyshire; Ulf Ribacke; Amanda K Lukens; Sofia A Santos; Vishal Patel; Clary B Clish; William J Sullivan; Huihao Zhou; Selina E Bopp; Paul Schimmel; Susan Lindquist; Jon Clardy; Maria M Mota; Tracy L Keller; Malcolm Whitman; Olaf Wiest; Dyann F Wirth; Ralph Mazitschek
Journal:  Sci Transl Med       Date:  2015-05-20       Impact factor: 17.956
  1 in total

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