Literature DB >> 15996941

Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia.

Emmanuel Raffoux, Pascal Chaibi, Hervé Dombret, Laurent Degos.   

Abstract

Valproic acid (VPA) has been demonstrated to be able to inhibit histone deacetylase activity and to synergize with all-trans retinoic acid (ATRA) in inducing the differentiation of acute myeloid leukemia (AML) cells. A pilot study of the VPA/ATRA combination was performed in 11 elderly patients with de novo AML (median age, 82 years). Complete marrow response was observed in 3 patients, including 1 complete remission. Two additional patients had hematologic improvement.

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Year:  2005        PMID： 15996941

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  27 in total

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