Literature DB >> 15996936

Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia.

Raimundo N P Costa, Nicola Conran, Dulcineia M Albuquerque, Paulo H Soares, Sara T O Saad, Fernando Ferreira Costa.   

Abstract

Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.

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Year:  2005        PMID： 15996936

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  3 in total

1.  Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.

Authors:  A Driss; K O Asare; J M Hibbert; B E Gee; T V Adamkiewicz; J K Stiles
Journal:  Genomics Insights       Date:  2009-07-30

Review 2.  Sickle Cell Anemia and Its Phenotypes.

Authors:  Thomas N Williams; Swee Lay Thein
Journal:  Annu Rev Genomics Hum Genet       Date:  2018-04-11       Impact factor: 9.340

3.  Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia.

Authors:  Fatou Gueye Tall; Cyril Martin; El Hadji Malick Ndour; Camille Faes; Indou Déme Ly; Vincent Pialoux; Philippe Connes; Papa Madieye Gueye; Rokhaya Ndiaye Diallo; Céline Renoux; Ibrahima Diagne; Pape Amadou Diop; Aynina Cissé; Philomène Lopez Sall; Philippe Joly
Journal:  Antioxidants (Basel)       Date:  2020-09-14
  3 in total

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