| Literature DB >> 15996892 |
Massimo Locati1, Yeny Martinez de la Torre, Emanuela Galliera, Raffaella Bonecchi, Haribabu Bodduluri, Gianluca Vago, Annunciata Vecchi, Alberto Mantovani.
Abstract
The chemokine system includes at least three "silent" receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes.Entities:
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Year: 2005 PMID： 15996892 DOI： 10.1016/j.cytogfr.2005.05.003
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638