BACKGROUND: Treatment of vivax malaria with primaquine prevents the relapse of infection from residual liver stages of the parasite. Inadequate dosage is related to a higher relapse risk. METHODS: A comparison was made of vivax malaria relapse-prevention treatments with primaquine 22.5 mg or 30 mg daily for 14 days on 146 reports to the Australian Army Central Malaria Register. RESULTS: The lower dose of primaquine was found to carry a relative risk of 6.63 for a relapse of vivax malaria compared with the higher dose. CONCLUSIONS: The available data presented here suggest that vivax malaria in this region is increasingly tolerant of the 22.5 mg daily treatment regimen of primaquine and that the greater dose of at least 30 mg daily is more effective.
BACKGROUND: Treatment of vivax malaria with primaquine prevents the relapse of infection from residual liver stages of the parasite. Inadequate dosage is related to a higher relapse risk. METHODS: A comparison was made of vivax malaria relapse-prevention treatments with primaquine 22.5 mg or 30 mg daily for 14 days on 146 reports to the Australian Army Central Malaria Register. RESULTS: The lower dose of primaquine was found to carry a relative risk of 6.63 for a relapse of vivax malaria compared with the higher dose. CONCLUSIONS: The available data presented here suggest that vivax malaria in this region is increasingly tolerant of the 22.5 mg daily treatment regimen of primaquine and that the greater dose of at least 30 mg daily is more effective.
Authors: Aida M Soto; Lilia González-Cerón; Frida Santillán-Valenzuela; María E Parrales; Alberto Montoya Journal: Int J Environ Res Public Health Date: 2022-05-19 Impact factor: 4.614
Authors: Renata S Pedro; Lusiele Guaraldo; Dayse P Campos; Anielle P Costa; Cláudio T Daniel-Ribeiro; Patrícia Brasil Journal: Malar J Date: 2012-07-28 Impact factor: 2.979
Authors: Joel Tarning; Mavuto Mukaka; Walter Robert Taylor; Richard M Hoglund; Pimnara Peerawaranun; Thuy Nhien Nguyen; Tran Tinh Hien; Arnaud Tarantola; Lorenz von Seidlein; Rupam Tripura; Thomas J Peto; Arjen M Dondorp; Jordi Landier; Francois H Nosten; Frank Smithuis; Koukeo Phommasone; Mayfong Mayxay; Soy Ty Kheang; Chy Say; Kak Neeraj; Leang Rithea; Lek Dysoley; Sim Kheng; Sinoun Muth; Arantxa Roca-Feltrer; Mark Debackere; Rick M Fairhurst; Ngak Song; Philippe Buchy; Didier Menard; Nicholas J White Journal: Malar J Date: 2021-09-09 Impact factor: 2.979