OBJECTIVE: To investigate whether microbial DNA is present in synovial specimens from patients with Yersinia-triggered reactive arthritis. METHODS: Synovial specimens from 13 patients with Yersinia enterocolitica O:3-triggered reactive arthritis and from 16 control patients were studied using polymerase chain reaction and immunocytochemical staining techniques. RESULTS: Yersinia chromosomal DNA was not found in any of the synovial specimens from Yersinia-triggered arthritis patients or controls, whereas with immunocytochemical techniques, Yersinia antigens were observed in synovial specimens from all of the patients with Yersinia-triggered reactive arthritis. CONCLUSION: Only stable bacterial degradation products, not whole bacteria, are present at the site of inflammation in Yersinia-triggered reactive arthritis.
OBJECTIVE: To investigate whether microbial DNA is present in synovial specimens from patients with Yersinia-triggered reactive arthritis. METHODS: Synovial specimens from 13 patients with Yersinia enterocolitica O:3-triggered reactive arthritis and from 16 control patients were studied using polymerase chain reaction and immunocytochemical staining techniques. RESULTS:Yersinia chromosomal DNA was not found in any of the synovial specimens from Yersinia-triggered arthritispatients or controls, whereas with immunocytochemical techniques, Yersinia antigens were observed in synovial specimens from all of the patients with Yersinia-triggered reactive arthritis. CONCLUSION: Only stable bacterial degradation products, not whole bacteria, are present at the site of inflammation in Yersinia-triggered reactive arthritis.
Authors: K Rantakokko-Jalava; S Nikkari; J Jalava; E Eerola; M Skurnik; O Meurman; O Ruuskanen; A Alanen; E Kotilainen; P Toivanen; P Kotilainen Journal: J Clin Microbiol Date: 2000-01 Impact factor: 5.948
Authors: J Kriegsmann; T Hopf; D Jacobs; N Arens; V Krenn; R Schmitt-Wiedhoff; M Kriegsmann; C Heisel; C Biehl; H Thabe; R P H Schmitz; M Lehmann; M Otto Journal: Orthopade Date: 2009-06 Impact factor: 1.087
Authors: L Kupila; K Rantakokko-Jalava; J Jalava; S Nikkari; R Peltonen; O Meurman; R J Marttila; E Kotilainen; P Kotilainen Journal: J Neurol Neurosurg Psychiatry Date: 2003-06 Impact factor: 10.154