Literature DB >> 15995218

Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae.

Katherine M Hoffmann1, Daniel Williams, William M Shafer, Richard G Brennan.   

Abstract

MtrR represses expression of the Neisseria gonorrhoeae mtrCDE multidrug efflux transporter genes. MtrR displays salt-dependent DNA binding, a stoichiometry of two dimers per DNA site, and, for a protein that was expected to be essentially all helical, a high percentage of random coil and possibly beta-sheet structure.

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Year:  2005        PMID： 15995218      PMCID： PMC1169513          DOI： 10.1128/JB.187.14.5008-5012.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  24 in total

1.  Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system.

Authors:  P Orth; D Schnappinger; W Hillen; W Saenger; W Hinrichs
Journal:  Nat Struct Biol       Date:  2000-03

2.  The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.

Authors:  S Grkovic; M H Brown; M A Schumacher; R G Brennan; R A Skurray
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

3.  Structural mechanisms of QacR induction and multidrug recognition.

Authors:  M A Schumacher; M C Miller; S Grkovic; M H Brown; R A Skurray; R G Brennan
Journal:  Science       Date:  2001-12-07       Impact factor: 47.728

4.  Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.

Authors:  Maria A Schumacher; Marshall C Miller; Steve Grkovic; Melissa H Brown; Ronald A Skurray; Richard G Brennan
Journal:  EMBO J       Date:  2002-03-01       Impact factor: 11.598

5.  Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators.

Authors:  Jan D Kahmann; Hans-Jürgen Sass; Martin G Allan; Haruo Seto; Charles J Thompson; Stephan Grzesiek
Journal:  EMBO J       Date:  2003-04-15       Impact factor: 11.598

Review 6.  Regulation of bacterial drug export systems.

Authors:  Steve Grkovic; Melissa H Brown; Ronald A Skurray
Journal:  Microbiol Mol Biol Rev       Date:  2002-12       Impact factor: 11.056

7.  Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance.

Authors:  Paul Stapleton; Victoria Adams; Rachel Pike; Victoria Lucas; Graham Roberts; Peter Mullany; Robin Rowbury; Michael Wilson; Hilary Richards
Journal:  Int J Antimicrob Agents       Date:  2004-11       Impact factor: 5.283

8.  EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.

Authors:  Jean Engohang-Ndong; David Baillat; Marc Aumercier; Flore Bellefontaine; Gurdyal S Besra; Camille Locht; Alain R Baulard
Journal:  Mol Microbiol       Date:  2004-01       Impact factor: 3.501

9.  Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2).

Authors:  Ryo Natsume; Yasuo Ohnishi; Toshiya Senda; Sueharu Horinouchi
Journal:  J Mol Biol       Date:  2004-02-13       Impact factor: 5.469

10.  The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system.

Authors:  Kayla E Hagman; Claressa E Lucas; Jacqueline T Balthazar; Lori Snyder; Matthew Nilles; Ralph C Judd; William M Shafer
Journal:  Microbiology (Reading)       Date:  1997-07       Impact factor: 2.777
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  27 in total

1.  Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

Authors:  Chih-Chia Su; Hiroshi Nikaido; Edward W Yu
Journal:  FEBS Lett       Date:  2007-09-25       Impact factor: 4.124

2.  Characterization of the multidrug efflux regulator AcrR from Escherichia coli.

Authors:  Chih-Chia Su; Denae J Rutherford; Edward W Yu
Journal:  Biochem Biophys Res Commun       Date:  2007-07-17       Impact factor: 3.575

3.  Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa.

Authors:  Sean J Johnson; Devin Close; Howard Robinson; Isabelle Vallet-Gely; Simon L Dove; Christopher P Hill
Journal:  J Mol Biol       Date:  2008-02-12       Impact factor: 5.469

4.  Differential regulation of ponA and pilMNOPQ expression by the MtrR transcriptional regulatory protein in Neisseria gonorrhoeae.

Authors:  Jason P Folster; Vijaya Dhulipala; Robert A Nicholas; William M Shafer
Journal:  J Bacteriol       Date:  2007-05-04       Impact factor: 3.490

5.  Phenotypic and genotypic analyses of Neisseria gonorrhoeae isolates that express frequently recovered PorB PIA variable region types suggest that certain P1a porin sequences confer a selective advantage for urogenital tract infection.

Authors:  Lotisha E Garvin; Margaret C Bash; Christine Keys; Douglas M Warner; Sanjay Ram; William M Shafer; Ann E Jerse
Journal:  Infect Immun       Date:  2008-06-09       Impact factor: 3.441

6.  MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae.

Authors:  Jason P Folster; Paul J T Johnson; Lydgia Jackson; Vijaya Dhulipali; David W Dyer; William M Shafer
Journal:  J Bacteriol       Date:  2008-10-31       Impact factor: 3.490

Review 7.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

8.  Off-target gene regulation mediated by transcriptional repressors of antimicrobial efflux pump genes in Neisseria gonorrhoeae.

Authors:  Paul J T Johnson; Virginia A Stringer; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

Review 9.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

10.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulator AcrR from Escherichia coli.

Authors:  Ming Li; Xi Qiu; Chih-Chia Su; Feng Long; Ruoyu Gu; Gerry McDermott; Edward W Yu
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-10-20
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