Literature DB >> 15994826

Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.

Mindy S Lo1, Robert M Brazas, Michael J Holtzman.   

Abstract

Respiratory syncytial virus (RSV) subverts the antiviral interferon (IFN) response, but the mechanism for this evasion was unclear. Here we show that RSV preferentially inhibits IFN-alpha/beta signaling by expression of viral NS1 and NS2. Thus, RSV infection or expression of recombinant NS1 and NS2 in epithelial host cells causes a marked decrease in Stat2 levels and the consequent downstream IFN-alpha/beta response. Similarly, NS1/NS2-deficient RSV no longer decreases Stat2 levels or IFN responsiveness. RSV infection decreased human but not mouse Stat2 levels, so this mechanism of IFN antagonism may contribute to viral host range, as well as immune subversion.

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Year:  2005        PMID： 15994826      PMCID： PMC1168759          DOI： 10.1128/JVI.79.14.9315-9319.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells.

Authors:  Birgit Bossert; Karl-Klaus Conzelmann
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

2.  Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons.

Authors:  J Andrejeva; D F Young; S Goodbourn; R E Randall
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

Review 3.  Paramyxovirus accessory proteins as interferon antagonists.

Authors:  B Gotoh; T Komatsu; K Takeuchi; J Yokoo
Journal:  Microbiol Immunol       Date:  2001       Impact factor: 1.955

4.  Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins.

Authors:  Jean-Francois Valarcher; Julie Furze; Sara Wyld; Roy Cook; Karl-Klaus Conzelmann; Geraldine Taylor
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

5.  Specific inhibition of type I interferon signal transduction by respiratory syncytial virus.

Authors:  Murali Ramaswamy; Lei Shi; Martha M Monick; Gary W Hunninghake; Dwight C Look
Journal:  Am J Respir Cell Mol Biol       Date:  2004-01-12       Impact factor: 6.914

6.  Evaluation of recombinant respiratory syncytial virus gene deletion mutants in African green monkeys for their potential as live attenuated vaccine candidates.

Authors:  Hong Jin; Xing Cheng; Vicki L Traina-Dorge; Hyun Jung Park; Helen Zhou; Ken Soike; George Kemble
Journal:  Vaccine       Date:  2003-09-08       Impact factor: 3.641

7.  Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000.

Authors:  Shelah Leader; Kimmie Kohlhase
Journal:  J Pediatr       Date:  2003-11       Impact factor: 4.406

8.  The C protein of measles virus inhibits the type I interferon response.

Authors:  Jessica A Shaffer; William J Bellini; Paul A Rota
Journal:  Virology       Date:  2003-10-25       Impact factor: 3.616

9.  Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected].

Authors:  Kirsten M Spann; Kim-C Tran; Bo Chi; Ronald L Rabin; Peter L Collins
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

10.  STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.

Authors:  Heidi Palosaari; Jean-Patrick Parisien; Jason J Rodriguez; Christina M Ulane; Curt M Horvath
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103
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  144 in total

1.  Mouse STAT2 restricts early dengue virus replication.

Authors:  Joseph Ashour; Juliet Morrison; Maudry Laurent-Rolle; Alan Belicha-Villanueva; Courtney Ray Plumlee; Dabeiba Bernal-Rubio; Katherine L Williams; Eva Harris; Ana Fernandez-Sesma; Christian Schindler; Adolfo García-Sastre
Journal:  Cell Host Microbe       Date:  2010-11-18       Impact factor: 21.023

2.  Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro.

Authors:  Anna R Kwilas; Mark A Yednak; Liqun Zhang; Rachael Liesman; Peter L Collins; Raymond J Pickles; Mark E Peeples
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

Review 3.  Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease.

Authors:  Michael J Holtzman; Jeffrey W Tyner; Edy Y Kim; Mindy S Lo; Anand C Patel; Laurie P Shornick; Eugene Agapov; Yong Zhang
Journal:  Proc Am Thorac Soc       Date:  2005

4.  Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze.

Authors:  Kedir N Turi; Jyoti Shankar; Larry J Anderson; Devi Rajan; Kelsey Gaston; Tebeb Gebretsadik; Suman R Das; Cosby Stone; Emma K Larkin; Christian Rosas-Salazar; Steven M Brunwasser; Martin L Moore; R Stokes Peebles; Tina V Hartert
Journal:  Am J Respir Crit Care Med       Date:  2018-10-15       Impact factor: 21.405

Review 5.  A centennial history of research on asthma pathogenesis.

Authors:  Michael J Walter; Michael J Holtzman
Journal:  Am J Respir Cell Mol Biol       Date:  2005-06       Impact factor: 6.914

6.  Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

Authors:  Jeffrey W Tyner; Edy Y Kim; Kyotaro Ide; Mark R Pelletier; William T Roswit; Jeffrey D Morton; John T Battaile; Anand C Patel; G Alexander Patterson; Mario Castro; Melanie S Spoor; Yingjian You; Steven L Brody; Michael J Holtzman
Journal:  J Clin Invest       Date:  2006-02       Impact factor: 14.808

7.  Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.

Authors:  Joanne Elliott; Oonagh T Lynch; Yvonne Suessmuth; Ping Qian; Caroline R Boyd; James F Burrows; Richard Buick; Nigel J Stevenson; Olivier Touzelet; Massimo Gadina; Ultan F Power; James A Johnston
Journal:  J Virol       Date:  2007-01-24       Impact factor: 5.103

Review 8.  Immunogenetic programs for viral induction of mucous cell metaplasia.

Authors:  Michael J Holtzman; John T Battaile; Anand C Patel
Journal:  Am J Respir Cell Mol Biol       Date:  2006-03-16       Impact factor: 6.914

9.  Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells.

Authors:  Shirin Munir; Cyril Le Nouen; Cindy Luongo; Ursula J Buchholz; Peter L Collins; Alexander Bukreyev
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

10.  Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism.

Authors:  Michael J Ciancanelli; Valentina A Volchkova; Megan L Shaw; Viktor E Volchkov; Christopher F Basler
Journal:  J Virol       Date:  2009-06-10       Impact factor: 5.103
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