Literature DB >> 15994182

Beyond the brush border: NHERF4 blazes new NHERF turf.

William R Thelin1, Caleb A Hodson, Sharon L Milgram.   

Abstract

The Na exchanger regulatory factor (NHERF) family of epithelial-enriched PDZ domain scaffolding proteins plays important roles in maintaining and regulating epithelial cell function. The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting redundant functions. Yet, it is clear that each NHERF protein exhibits distinct properties, translating into unique cellular functions. The work summarized in this review suggests the most recently identified family member, NHERF4, is the most divergent. Additional investigation is needed, however, to understand more completely the role of NHERF4 in the context of the NHERF family.

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Year:  2005        PMID： 15994182      PMCID： PMC1474171          DOI： 10.1113/jphysiol.2005.091041

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  46 in total

1.  C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins.

Authors:  Tamás Hegedüs; Tamás Sessler; Robert Scott; William Thelin; Eva Bakos; András Váradi; Katalin Szabó; László Homolya; Sharon L Milgram; Balázs Sarkadi
Journal:  Biochem Biophys Res Commun       Date:  2003-03-14       Impact factor: 3.575

2.  cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.

Authors:  M Zizak; G Lamprecht; D Steplock; N Tariq; S Shenolikar; M Donowitz; C H Yun; E J Weinman
Journal:  J Biol Chem       Date:  1999-08-27       Impact factor: 5.157

3.  Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

Authors:  Z Songyang; A S Fanning; C Fu; J Xu; S M Marfatia; A H Chishti; A Crompton; A C Chan; J M Anderson; L C Cantley
Journal:  Science       Date:  1997-01-03       Impact factor: 47.728

4.  Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains.

Authors:  O Kocher; N Comella; K Tognazzi; L F Brown
Journal:  Lab Invest       Date:  1998-01       Impact factor: 5.662

5.  Identification of a new gene product (diphor-1) regulated by dietary phosphate.

Authors:  M Custer; B Spindler; F Verrey; H Murer; J Biber
Journal:  Am J Physiol       Date:  1997-11

6.  G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.

Authors:  R A Hall; R F Spurney; R T Premont; N Rahman; J T Blitzer; J A Pitcher; R J Lefkowitz
Journal:  J Biol Chem       Date:  1999-08-20       Impact factor: 5.157

7.  Epitope conservation and immunohistochemical localization of the guanylin/stable toxin peptide receptor, guanylyl cyclase C.

Authors:  A Nandi; R Bhandari; S S Visweswariah
Journal:  J Cell Biochem       Date:  1997-09-15       Impact factor: 4.429

8.  An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton.

Authors:  D B Short; K W Trotter; D Reczek; S M Kreda; A Bretscher; R C Boucher; M J Stutts; S L Milgram
Journal:  J Biol Chem       Date:  1998-07-31       Impact factor: 5.157

9.  Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.

Authors:  D Reczek; M Berryman; A Bretscher
Journal:  J Cell Biol       Date:  1997-10-06       Impact factor: 10.539

Review 10.  Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures.

Authors:  A Bretscher; D Reczek; M Berryman
Journal:  J Cell Sci       Date:  1997-12       Impact factor: 5.285
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  13 in total

1.  Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.

Authors:  M Donowitz; S Singh; P Singh; M Chakraborty; Y Chen; R Murtazina; M Gucek; R N Cole; N C Zachos; F F Salahuddin; O Kovbasnjuk; N Broere; W G Smalley-Freed; A B Reynolds; A L Hubbard; U Seidler; E Weinman; H R de Jonge; B M Hogema; X Li
Journal:  Physiol Genomics       Date:  2011-03-22       Impact factor: 3.107

2.  Structural basis for NHERF1 PDZ domain binding.

Authors:  Tatyana Mamonova; Maria Kurnikova; Peter A Friedman
Journal:  Biochemistry       Date:  2012-03-27       Impact factor: 3.162

3.  Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.

Authors:  Stan F J van de Graaf; Joost G J Hoenderop; Annemiete W C M van der Kemp; Serge M Gisler; René J M Bindels
Journal:  Pflugers Arch       Date:  2006-03-25       Impact factor: 3.657

Review 4.  Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors.

Authors:  Juan A Ardura; Peter A Friedman
Journal:  Pharmacol Rev       Date:  2011-08-26       Impact factor: 25.468

5.  Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.

Authors:  Mingmin Chen; Ayesha Sultan; Ayhan Cinar; Sunil Yeruva; Brigitte Riederer; Anurag Kumar Singh; Junhua Li; Janina Bonhagen; Gang Chen; Chris Yun; Mark Donowitz; Boris Hogema; Hugo de Jonge; Ursula Seidler
Journal:  J Physiol       Date:  2010-12-15       Impact factor: 5.182

6.  Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.

Authors:  Jie Hu; Zhonghua Zhang; Wen-Jun Shen; Salman Azhar
Journal:  Nutr Metab (Lond)       Date:  2010-06-01       Impact factor: 4.169

7.  Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Authors:  Nicholas C Zachos; Caleb Hodson; Olga Kovbasnjuk; Xuhang Li; William R Thelin; Boyoung Cha; Sharon Milgram; Mark Donowitz
Journal:  Cell Physiol Biochem       Date:  2008-12-09

8.  NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.

Authors:  Nicholas C Zachos; Xuhang Li; Olga Kovbasnjuk; Boris Hogema; Rafiquel Sarker; Luke J Lee; Min Li; Hugo de Jonge; Mark Donowitz
Journal:  J Biol Chem       Date:  2009-06-17       Impact factor: 5.157

9.  Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

Authors:  Anurag Kumar Singh; Brigitte Riederer; Anja Krabbenhöft; Brigitte Rausch; Janina Bonhagen; Ulrich Lehmann; Hugo R de Jonge; Mark Donowitz; Chris Yun; Edward J Weinman; Olivier Kocher; Boris M Hogema; Ursula Seidler
Journal:  J Clin Invest       Date:  2009-02-16       Impact factor: 14.808

10.  A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.

Authors:  Shibani Bhattacharya; Zhongping Dai; Jianquan Li; Sabine Baxter; David J E Callaway; David Cowburn; Zimei Bu
Journal:  J Biol Chem       Date:  2009-12-30       Impact factor: 5.157
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