Literature DB >> 15994064

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder.

Marijn Lijffijt1, J Leon Kenemans, Annemiek ter Wal, Elise H Quik, C Kemner, Herman Westenberg, Marinus N Verbaten, Herman van Engeland.   

Abstract

PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention. SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.
RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively. DISCUSSION AND
CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

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Year:  2005        PMID： 15994064     DOI： 10.1016/j.eurpsy.2005.04.003

Source DB:  PubMed          Journal:  Eur Psychiatry        ISSN： 0924-9338            Impact factor:   5.361


  20 in total

1.  Methylphenidate enhances prepulse inhibition during processing of task-relevant stimuli in attention-deficit/hyperactivity disorder.

Authors:  Rebecca L Ashare; Larry W Hawk; Keri Shiels; Jessica D Rhodes; William E Pelham; James G Waxmonsky
Journal:  Psychophysiology       Date:  2010-03-10       Impact factor: 4.016

Review 2.  The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks.

Authors:  Dawn M Eagle; Andrea Bari; Trevor W Robbins
Journal:  Psychopharmacology (Berl)       Date:  2008-06-10       Impact factor: 4.530

3.  Haloperidol 2 mg impairs inhibition but not visuospatial attention.

Authors:  H N Alexander Logemann; Koen B E Böcker; Peter K H Deschamps; Peter N van Harten; Jeroen Koning; Chantal Kemner; Zsófia Logemann-Molnár; J Leon Kenemans
Journal:  Psychopharmacology (Berl)       Date:  2016-10-17       Impact factor: 4.530

Review 4.  Pharmacological models of ADHD.

Authors:  R M Kostrzewa; J P Kostrzewa; R A Kostrzewa; P Nowak; R Brus
Journal:  J Neural Transm (Vienna)       Date:  2007-11-12       Impact factor: 3.575

5.  Genetic associations with reflexive visual attention in infancy and childhood.

Authors:  Rebecca A Lundwall; James L Dannemiller; H Hill Goldsmith
Journal:  Dev Sci       Date:  2015-11-27

6.  The Effects of Methylphenidate on Neural Substrates Associated with Interference Suppression in Children with ADHD: A Preliminary Study Using Event Related fMRI.

Authors:  Young-Sik Lee; Doug Hyun Han; Jang Han Lee; Tae Young Choi
Journal:  Psychiatry Investig       Date:  2010-02-08       Impact factor: 2.505

7.  Response disinhibition evoked by the administration of nicotine and nicotine-associated contextual cues.

Authors:  Ari P Kirshenbaum; Matthew W Johnson; Sarah L Schwarz; Eric R Jackson
Journal:  Drug Alcohol Depend       Date:  2009-07-28       Impact factor: 4.492

8.  Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate.

Authors:  Fleur L Warton; Fleur M Howells; Vivienne A Russell
Journal:  Metab Brain Dis       Date:  2009-10-10       Impact factor: 3.584

9.  Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD).

Authors:  Elise E DeVito; Andrew D Blackwell; Luke Clark; Lindsey Kent; Anna Maria Dezsery; Danielle C Turner; Michael R F Aitken; Barbara J Sahakian
Journal:  Psychopharmacology (Berl)       Date:  2008-09-26       Impact factor: 4.530

Review 10.  Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition.

Authors:  Dawn M Eagle; Christelle Baunez
Journal:  Neurosci Biobehav Rev       Date:  2009-07-15       Impact factor: 8.989
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