| Literature DB >> 15993616 |
Ji-Yan Pang1, Yong Qin, Wen-Hua Chen, Guo-An Luo, Zhi-Hong Jiang.
Abstract
Four new monomodified berberines have been synthesized in moderate to good yields starting from berberine and fully characterized by HRMS and 1H NMR. Spectrometric titration and ethidium bromide displacement experiments indicate that these berberine derivatives, especially the one having primary amino group, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism.Entities:
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Year: 2005 PMID： 15993616 DOI： 10.1016/j.bmc.2005.05.048
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641