Literature DB >> 15993614

Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs.

Gloria V López1, Carlos Batthyány, Fabiana Blanco, Horacio Botti, Andrés Trostchansky, Eduardo Migliaro, Rafael Radi, Mercedes González, Hugo Cerecetto, Homero Rubbo.   

Abstract

Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.

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Year:  2005        PMID: 15993614     DOI: 10.1016/j.bmc.2005.05.060

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  2 in total

1.  Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates.

Authors:  Yuliya V Yushkova; Elena I Chernyak; Yuriy V Gatilov; Vladimir G Vasil'ev; Sergey V Morozov; Igor A Grigor'ev
Journal:  Saudi Pharm J       Date:  2017-10-10       Impact factor: 4.330

2.  Design, Synthesis and Study of Nitrogen Monoxide Donors as Potent Hypolipidaemic and Anti-Inflammatory Agents.

Authors:  Panagiotis Theodosis-Nobelos; Georgios Papagiouvanis; Maria Pantelidou; Panos N Kourounakis; Chrysoula Athanasekou; Eleni A Rekka
Journal:  Molecules       Date:  2019-12-19       Impact factor: 4.411

  2 in total

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