Literature DB >> 15993600

Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.

Rong Sheng1, Xiao Lin, Jingya Li, Yanke Jiang, Zhicai Shang, Yongzhou Hu.   

Abstract

A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.

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Year:  2005        PMID： 15993600     DOI： 10.1016/j.bmcl.2005.05.132

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets.

Authors:  Md Sahab Uddin; Abdullah Al Mamun; Md Tanvir Kabir; Ghulam Md Ashraf; May N Bin-Jumah; Mohamed M Abdel-Daim
Journal:  Mol Neurobiol       Date:  2020-09-15       Impact factor: 5.590

Review 2.  Hybrids: a new paradigm to treat Alzheimer's disease.

Authors:  Manjinder Singh; Maninder Kaur; Navriti Chadha; Om Silakari
Journal:  Mol Divers       Date:  2015-09-02       Impact factor: 2.943

3.  Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors.

Authors:  Lu Kang; Xiao-Hui Gao; Hao-Ran Liu; Xue Men; Hong-Nian Wu; Pei-Wu Cui; Eric Oldfield; Jian-Ye Yan
Journal:  Mol Divers       Date:  2018-06-22       Impact factor: 2.943

4.  Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.

Authors:  Suresh K Bowroju; Narsimha R Penthala; Naga Rajiv Lakkaniga; Meenakshisundaram Balasubramaniam; Srinivas Ayyadevara; Robert J Shmookler Reis; Peter A Crooks
Journal:  Bioorg Med Chem       Date:  2021-07-14       Impact factor: 3.461

5.  Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking.

Authors:  Muhammad Yar; Marek Bajda; Rana Atif Mehmood; Lala Rukh Sidra; Nisar Ullah; Lubna Shahzadi; Muhammad Ashraf; Tayaba Ismail; Sohail Anjum Shahzad; Zulfiqar Ali Khan; Syed Ali Raza Naqvi; Nasir Mahmood
Journal:  Lett Drug Des Discov       Date:  2014-03       Impact factor: 1.150

6.  Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase.

Authors:  C David Andersson; J Mikael Hillgren; Cecilia Lindgren; Weixing Qian; Christine Akfur; Lotta Berg; Fredrik Ekström; Anna Linusson
Journal:  J Comput Aided Mol Des       Date:  2014-10-29       Impact factor: 3.686

7.  Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?

Authors:  David Ramírez; Julio Caballero
Journal:  Int J Mol Sci       Date:  2016-04-20       Impact factor: 5.923

8.  Metabolism of BYZX in human liver microsomes and cytosol: identification of the metabolites and metabolic pathways of BYZX.

Authors:  Lushan Yu; Yan Jiang; Lu Wang; Rong Sheng; Yongzhou Hu; Su Zeng
Journal:  PLoS One       Date:  2013-03-29       Impact factor: 3.240

9.  A novel class of selective acetylcholinesterase inhibitors: synthesis and evaluation of (E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles.

Authors:  Pedro de la Torre; Luis Astudillo Saavedra; Julio Caballero; Jairo Quiroga; Jans H Alzate-Morales; Margarita Gutiérrez Cabrera; Jorge Trilleras
Journal:  Molecules       Date:  2012-10-15       Impact factor: 4.411
  9 in total

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