Literature DB >> 15993583

Synthesis of novel curcumin mimics with asymmetrical units and their anti-angiogenic activity.

Ho Bum Woo1, Woon-Seob Shin, Seokjoon Lee, Chan Mug Ahn.   

Abstract

Novel curcumin mimics with asymmetrical units phenyl group with alkyl amide, chloro-substituted benzamide, or heteroaromatic amide moieties were synthesized and their anti-angiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells. Compounds 5, 14, 17, and 18 showed potent growth inhibitory activity and tube formation inhibitory activity.

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Year:  2005        PMID： 15993583     DOI： 10.1016/j.bmcl.2005.05.064

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Curcumin: from ancient medicine to current clinical trials.

Authors:  H Hatcher; R Planalp; J Cho; F M Torti; S V Torti
Journal:  Cell Mol Life Sci       Date:  2008-06       Impact factor: 9.261

2.  High glucose decreases expression and activity of p-glycoprotein in cultured human retinal pigment epithelium possibly through iNOS induction.

Authors:  Yuehong Zhang; Chunmei Li; Xuerong Sun; Xielan Kuang; Xiangcai Ruan
Journal:  PLoS One       Date:  2012-02-17       Impact factor: 3.240

Review 3.  Natural phenolic metabolites with anti-angiogenic properties - a review from the chemical point of view.

Authors:  Qiu Sun; Jörg Heilmann; Burkhard König
Journal:  Beilstein J Org Chem       Date:  2015-02-16       Impact factor: 2.883

Review 4.  Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs).

Authors:  Dinesh Shetty; Yong Joon Kim; Hyunsuk Shim; James P Snyder
Journal:  Molecules       Date:  2014-12-24       Impact factor: 4.411
  4 in total

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