Literature DB >> 15993090

Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities.

Fliur Macaev1, Ghenadie Rusu, Serghei Pogrebnoi, Alexandru Gudima, Eugenia Stingaci, Ludmila Vlad, Nathaly Shvets, Fatma Kandemirli, Anatholy Dimoglo, Robert Reynolds.   

Abstract

The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.

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Year:  2005        PMID： 15993090     DOI： 10.1016/j.bmc.2005.05.011

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.

Authors:  Sarah Schmidt Grant; Samantha Wellington; Tomohiko Kawate; Christopher A Desjardins; Melanie R Silvis; Carl Wivagg; Matthew Thompson; Katherine Gordon; Edward Kazyanskaya; Raymond Nietupski; Nathan Haseley; Noriaki Iwase; Ashlee M Earl; Michael Fitzgerald; Deborah T Hung
Journal:  Cell Chem Biol       Date:  2016-06-16       Impact factor: 8.116

Review 2.  Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.

Authors:  Sean Ekins; Joel S Freundlich; Inhee Choi; Malabika Sarker; Carolyn Talcott
Journal:  Trends Microbiol       Date:  2010-12-02       Impact factor: 17.079

3.  Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives.

Authors:  Akhilesh Kumar; Saritha S D'Souza; S L Gaonkar; K M L Rai; Bharathi P Salimath
Journal:  Invest New Drugs       Date:  2008-01-29       Impact factor: 3.850

4.  Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.

Authors:  Isaac M Westwood; Sanjib Bhakta; Angela J Russell; Elizabeth Fullam; Matthew C Anderton; Akane Kawamura; Andrew W Mulvaney; Richard J Vickers; Veemal Bhowruth; Gurdyal S Besra; Ajit Lalvani; Stephen G Davies; Edith Sim
Journal:  Protein Cell       Date:  2010-03-18       Impact factor: 14.870

5.  Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones.

Authors:  Navin B Patel; Jaymin C Patel
Journal:  Sci Pharm       Date:  2010-04-26

6.  5-(5-Aryl-1,3,4-oxadiazole-2-carbonyl)furan-3-carboxylate and new cyclic C-glycoside analogues from carbohydrate precursors with MAO-B, antimicrobial and antifungal activities.

Authors:  Mohamed Mohamed El-Sadek; Seham Yassen Hassan; Nagwa Said Abd El-Dayem; Galila Ahmed Yacout
Journal:  Molecules       Date:  2012-06-07       Impact factor: 4.411

7.  Interactive data mining for molecular graphs.

Authors:  Burcu Yilmaz; Mehmet Göktürk
Journal:  J Autom Methods Manag Chem       Date:  2009-12-20

8.  Synthesis of new 2-amino-1,3,4-oxadiazole derivatives with anti-salmonella typhi activity evaluation.

Authors:  Eid E Salama
Journal:  BMC Chem       Date:  2020-04-20
  8 in total

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