Literature DB >> 15993065

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.

Timothy A Blizzard1, Frank DiNinno, Helen Y Chen, Seongkon Kim, Jane Y Wu, Wanda Chan, Elizabeth T Birzin, Yi Tien Yang, Lee-Yuh Pai, Edward C Hayes, Carolyn A DaSilva, Susan P Rohrer, James M Schaeffer, Milton L Hammond.   

Abstract

An optimized side chain for dihydrobenzoxathiin SERAMs was discovered and attached to four dihydrobenzoxathiin platforms. The novel SERAMs show exceptional estrogen antagonist activity in uterine tissue and an MCF-7 breast cancer cell assay.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15993065     DOI： 10.1016/j.bmcl.2005.05.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Structural plasticity in the oestrogen receptor ligand-binding domain.

Authors:  Kendall W Nettles; John B Bruning; German Gil; Erin E O'Neill; Jason Nowak; Yuee Guo; Alun Hughs; Younchang Kim; Eugene R DeSombre; Robert Dilis; Robert N Hanson; Andrzej Joachimiak; Geoffrey L Greene
Journal:  EMBO Rep       Date:  2007-04-27       Impact factor: 8.807

2.  Prediction of binding affinity for estrogen receptor alpha modulators using statistical learning approaches.

Authors:  Yonghua Wang; Yan Li; Jun Ding; Yuan Wang; Yaqing Chang
Journal:  Mol Divers       Date:  2008-07-26       Impact factor: 2.943

3.  Metal-free O-H/C-H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water.

Authors:  Dengfeng Chen; Qingyuan Feng; Yunqin Yang; Xu-Min Cai; Fei Wang; Shenlin Huang
Journal:  Chem Sci       Date:  2016-11-04       Impact factor: 9.825
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.