Literature DB >> 15993060

Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.

Michael J Alberti1, Elizabeth P Auten, Karen E Lackey, Octerloney B McDonald, Edgar R Wood, Frank Preugschat, Geoffrey J Cutler, Laurie Kane-Carson, Wei Liu, David K Jung.   

Abstract

The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines as potent kinase inhibitors are discussed.

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Year:  2005        PMID： 15993060     DOI： 10.1016/j.bmcl.2005.05.100

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition.

Authors:  Mater H Mahnashi; Fardous F El-Senduny; Mohammed Abdulrahman Alshahrani; Mahrous A Abou-Salim
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-18

2.  Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions.

Authors:  Abdelaziz Ejjoummany; Rabia Belaroussi; Ahmed El Hakmaoui; Mohamed Akssira; Gérald Guillaumet; Frédéric Buron; Sylvain Routier
Journal:  Molecules       Date:  2018-10-23       Impact factor: 4.411
  2 in total

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