OBJECTIVE: The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration. METHODS: Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies. RESULTS: High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p < 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found. CONCLUSION: NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies.
OBJECTIVE: The prognostic influence of neuroendocrine (NE) differentiation in prostate cancerpatients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration. METHODS:Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies. RESULTS: High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p < 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found. CONCLUSION: NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies.
Authors: Lawrence True; Ilsa Coleman; Sarah Hawley; Ching-Ying Huang; David Gifford; Roger Coleman; Tomasz M Beer; Edward Gelmann; Milton Datta; Elahe Mostaghel; Beatrice Knudsen; Paul Lange; Robert Vessella; Daniel Lin; Leroy Hood; Peter S Nelson Journal: Proc Natl Acad Sci U S A Date: 2006-07-07 Impact factor: 11.205
Authors: David S Priemer; Rodolfo Montironi; Lisha Wang; Sean R Williamson; Antonio Lopez-Beltran; Liang Cheng Journal: Endocr Pathol Date: 2016-06 Impact factor: 3.943
Authors: Andreas G Wibmer; Irene A Burger; Evis Sala; Hedvig Hricak; Wolfgang A Weber; Hebert Alberto Vargas Journal: Radiographics Date: 2015-11-20 Impact factor: 5.333