Inflammation and remodelling in the ageing airway.

WHAT WE NEED TO KNOW: What changes occur in atopic and non-atopic airway inflammation in asthma with increasing age? What is the relationship between wound healing and airway remodelling in older subjects? What is the response to anti-inflammatory therapy in older subjects? What is the basis of the "overlap syndrome" with chronic obstructive pulmonary disease in older people with asthma, in whom smoking contributes to airway disease? WHAT WE NEED TO DO: Identify the contribution of immunological mechanisms to asthma in ageing. Determine the extent to which airway remodelling plays a role in airflow obstruction in older people, specifically reversible components. Reduce the impact of smoking in young people with asthma.