BACKGROUND: Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive. Ozone therapy is a nonconventional therapy that has been reported to offer benefits in late-onset wound healing and ischemic disorders. This report describes a patient with progressive radiation-induced hematuria from standard conservative treatment that was further treated with ozone therapy. METHOD: Ozone therapy was achieved by intravesical instillation of ozonized bi-distilled water over a period of 30 minutes, three sessions per week during the first weeks. Later, ozone therapy sessions were decreased and involved ozonized water or direct intravesicular instillation of ozone at 20-25 microg/mL. RESULTS: Hematuria was successfully controlled by intravesical application of ozone therapy. CONCLUSIONS: The successes achieved with this technique suggest that intravesicular instillation of ozonized bi-distilled water or ozone merits further investigation with a view to its application to counter this radiation-induced side-effect.
BACKGROUND: Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive. Ozone therapy is a nonconventional therapy that has been reported to offer benefits in late-onset wound healing and ischemic disorders. This report describes a patient with progressive radiation-induced hematuria from standard conservative treatment that was further treated with ozone therapy. METHOD:Ozone therapy was achieved by intravesical instillation of ozonized bi-distilled water over a period of 30 minutes, three sessions per week during the first weeks. Later, ozone therapy sessions were decreased and involved ozonized water or direct intravesicular instillation of ozone at 20-25 microg/mL. RESULTS:Hematuria was successfully controlled by intravesical application of ozone therapy. CONCLUSIONS: The successes achieved with this technique suggest that intravesicular instillation of ozonized bi-distilled water or ozone merits further investigation with a view to its application to counter this radiation-induced side-effect.
Authors: Arif Aslaner; Tuğrul Çakır; Betül Çelik; Uğur Doğan; Burhan Mayir; Cebrail Akyüz; Cemal Polat; Ahmet Baştürk; Vural Soyer; Süleyman Koç; Ahmet Özer Şehirli Journal: Int J Clin Exp Med Date: 2015-08-15
Authors: Kerem Teke; Tayyar A Ozkan; Oguz O Cebeci; Hasan Yilmaz; Muhammed E Keles; Levend Ozkan; Meltem O Dillioglugil; Demir K Yildiz; Ozdal Dillioglugil Journal: Exp Anim Date: 2017-02-22
Authors: Richard Megele; Markus J Riemenschneider; Frank Dodoo-Schittko; Matthias Feyrer; Andrea Kleindienst Journal: Oncol Lett Date: 2018-09-05 Impact factor: 2.967