OBJECTIVE: We investigated the replicability of the magnetically measured mismatch negativity (MMNm). METHODS: The MMNm was recorded twice by using a 122-channel whole-head magnetometer in 15 healthy young adults. The MMNm responses for duration, intensity and frequency deviants were analyzed separately in left and right hemispheres for the response strength, latency, dipole moment, and generator loci. RESULTS: In the right hemisphere, the test-retest correlations were statistically significant for all MMNm parameters (r = 0.49-0.89). In the left hemisphere, the majority of the MMNm parameters also demonstrated statistically significant test-retest correlations (r = 0.61-0.82). In addition, the MMNm generator loci were stable for all deviants. CONCLUSIONS AND SIGNIFICANCE: The present results are encouraging in terms of both research and clinical use of MMNm in studying human auditory discrimination in its normal and deteriorated states.
OBJECTIVE: We investigated the replicability of the magnetically measured mismatch negativity (MMNm). METHODS: The MMNm was recorded twice by using a 122-channel whole-head magnetometer in 15 healthy young adults. The MMNm responses for duration, intensity and frequency deviants were analyzed separately in left and right hemispheres for the response strength, latency, dipole moment, and generator loci. RESULTS: In the right hemisphere, the test-retest correlations were statistically significant for all MMNm parameters (r = 0.49-0.89). In the left hemisphere, the majority of the MMNm parameters also demonstrated statistically significant test-retest correlations (r = 0.61-0.82). In addition, the MMNm generator loci were stable for all deviants. CONCLUSIONS AND SIGNIFICANCE: The present results are encouraging in terms of both research and clinical use of MMNm in studying human auditory discrimination in its normal and deteriorated states.
Authors: Mackenzie C Cervenka; Piotr J Franaszczuk; Nathan E Crone; Bo Hong; Brian S Caffo; Paras Bhatt; Frederick A Lenz; Dana Boatman-Reich Journal: Clin Neurophysiol Date: 2012-07-06 Impact factor: 3.708
Authors: Teppo Särkämö; Mari Tervaniemi; Seppo Soinila; Taina Autti; Heli M Silvennoinen; Matti Laine; Marja Hietanen; Elina Pihko Journal: PLoS One Date: 2010-12-02 Impact factor: 3.240
Authors: W Ross Fulham; Patricia T Michie; Philip B Ward; Paul E Rasser; Juanita Todd; Patrick J Johnston; Paul M Thompson; Ulrich Schall Journal: PLoS One Date: 2014-06-20 Impact factor: 3.240