Roberta B Ness1, Carl A Hubel. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. repro@pitt.edu
Abstract
PURPOSE: A predisposition to coronary artery disease (CAD) may put women at risk for preeclampsia. Morbid preeclampsia (early, severe, recurrent, and with neonatal morbidity) represents the subset of preeclampsia of greatest public health concern. METHODS: We review here the published links between preeclampsia and CAD. RESULTS: Many risk factors are common to both CAD and preeclampsia. These include obesity; elevated blood pressure; dyslipidemia; insulin resistance; and hyperglycemia, together termed "Syndrome X"; as well as endothelial dysfunction; hyperuricemia; hyperhomocysteinemia; and abnormalities of inflammation, thrombosis, and angiogenesis. After pregnancy, women with preeclampsia are more likely to experience later life CAD. CONCLUSIONS: Both the association between CAD risk factors and preeclampsia and the association between preeclampsia and later CAD appears to be more pronounced among the subset of women with morbid preeclampsia. Thus, women at elevated risk for CAD may be at particularly high risk for morbid preeclampsia and women with morbid preeclampsia may be those at highest risk for later life CAD.
PURPOSE: A predisposition to coronary artery disease (CAD) may put women at risk for preeclampsia. Morbid preeclampsia (early, severe, recurrent, and with neonatal morbidity) represents the subset of preeclampsia of greatest public health concern. METHODS: We review here the published links between preeclampsia and CAD. RESULTS: Many risk factors are common to both CAD and preeclampsia. These include obesity; elevated blood pressure; dyslipidemia; insulin resistance; and hyperglycemia, together termed "Syndrome X"; as well as endothelial dysfunction; hyperuricemia; hyperhomocysteinemia; and abnormalities of inflammation, thrombosis, and angiogenesis. After pregnancy, women with preeclampsia are more likely to experience later life CAD. CONCLUSIONS: Both the association between CAD risk factors and preeclampsia and the association between preeclampsia and later CAD appears to be more pronounced among the subset of women with morbid preeclampsia. Thus, women at elevated risk for CAD may be at particularly high risk for morbid preeclampsia and women with morbid preeclampsia may be those at highest risk for later life CAD.
Authors: Erica P Gunderson; Vicky Chiang; Cora E Lewis; Janet Catov; Charles P Quesenberry; Stephen Sidney; Gina S Wei; Roberta Ness Journal: Obstet Gynecol Date: 2008-12 Impact factor: 7.661
Authors: Ming-Lin Zhu; Jin-Ping Zhao; Ning Cui; Victor H Gonçalves-Rizzi; Jose S Possomato-Vieira; Regina A Nascimento; Carlos A Dias-Junior Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2017-12-21
Authors: Robin E Gandley; Jennifer Rohland; Yan Zhou; Eiji Shibata; Gail F Harger; Augustine Rajakumar; Valerian E Kagan; Nina Markovic; Carl A Hubel Journal: Hypertension Date: 2008-06-30 Impact factor: 10.190
Authors: Carl A Hubel; Robert W Powers; Sunna Snaedal; Hilary S Gammill; Roberta B Ness; James M Roberts; Reynir Arngrímsson Journal: Hypertension Date: 2008-04-14 Impact factor: 10.190