Literature DB >> 15990305

Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.

John F Miller1, Michael Brieger, Eric S Furfine, Richard J Hazen, Istvan Kaldor, David Reynolds, Ronald G Sherrill, Andrew Spaltenstein.   

Abstract

A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were against wild-type virus.

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Year:  2005        PMID： 15990305     DOI： 10.1016/j.bmcl.2005.05.129

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Authors:  Arun K Ghosh; Heather L Osswald; Gary Prato
Journal:  J Med Chem       Date:  2016-01-22       Impact factor: 7.446

2.  On the interpretation and interpretability of quantitative structure-activity relationship models.

Authors:  Rajarshi Guha
Journal:  J Comput Aided Mol Des       Date:  2008-09-11       Impact factor: 3.686

3.  In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.

Authors:  Christian Callebaut; Kirsten Stray; Luong Tsai; Matt Williams; Zheng-Yu Yang; Carina Cannizzaro; Stephanie A Leavitt; Xiaohong Liu; Kelly Wang; Bernard P Murray; Andrew Mulato; Marcos Hatada; Tina Priskich; Neil Parkin; Swami Swaminathan; William Lee; Gong-Xin He; Lianhong Xu; Tomas Cihlar
Journal:  Antimicrob Agents Chemother       Date:  2011-01-18       Impact factor: 5.191

4.  Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

Authors:  Cara A Mosley; Scott J Myers; Ernest E Murray; Rose Santangelo; Yesim A Tahirovic; Natalie Kurtkaya; Praseeda Mullasseril; Hongjie Yuan; Polina Lyuboslavsky; Phuong Le; Lawrence J Wilson; Manuel Yepes; Ray Dingledine; Stephen F Traynelis; Dennis C Liotta
Journal:  Bioorg Med Chem       Date:  2009-07-05       Impact factor: 3.641

Review 5.  Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

Authors:  Ashley N Matthew; Florian Leidner; Gordon J Lockbaum; Mina Henes; Jacqueto Zephyr; Shurong Hou; Desaboini Nageswara Rao; Jennifer Timm; Linah N Rusere; Debra A Ragland; Janet L Paulsen; Kristina Prachanronarong; Djade I Soumana; Ellen A Nalivaika; Nese Kurt Yilmaz; Akbar Ali; Celia A Schiffer
Journal:  Chem Rev       Date:  2021-01-07       Impact factor: 60.622
  5 in total

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