Literature DB >> 15990302

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase.

Douglas M Sammond1, Kristen E Nailor, James M Veal, Robert T Nolte, Liping Wang, Victoria B Knick, Sharon K Rudolph, Anne T Truesdale, Eldridge N Nartey, Jeffrey A Stafford, Rakesh Kumar, Mui Cheung.   

Abstract

A series of dianilinopyrimidineureas demonstrate potency as VEGFR2 kinase inhibitors.

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Year:  2005        PMID： 15990302     DOI： 10.1016/j.bmcl.2005.05.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.

Authors:  Timothy P Burkholder; Joshua R Clayton; Mark E Rempala; James R Henry; John M Knobeloch; David Mendel; Johnathan A McLean; Yan Hao; David A Barda; Eileen L Considine; Mark T Uhlik; Yuefeng Chen; Liandong Ma; Laura J Bloem; Jacqueline K Akunda; Denis J McCann; Manuel Sanchez-Felix; David K Clawson; Michael M Lahn; James J Starling
Journal:  Invest New Drugs       Date:  2011-03-01       Impact factor: 3.850

2.  Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach.

Authors:  Kingkan Sanphanya; Suvara K Wattanapitayakul; Suwadee Phowichit; Valery V Fokin; Opa Vajragupta
Journal:  Bioorg Med Chem Lett       Date:  2013-03-20       Impact factor: 2.823

3.  Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity.

Authors:  Zhengsheng Zhan; Jing Ai; Qiufeng Liu; Yinchun Ji; Tiantian Chen; Yechun Xu; Meiyu Geng; Wenhu Duan
Journal:  ACS Med Chem Lett       Date:  2014-03-26       Impact factor: 4.345

4.  Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.

Authors:  Joanne M Hildebrand; Maria C Tanzer; Isabelle S Lucet; Samuel N Young; Sukhdeep K Spall; Pooja Sharma; Catia Pierotti; Jean-Marc Garnier; Renwick C J Dobson; Andrew I Webb; Anne Tripaydonis; Jeffrey J Babon; Mark D Mulcair; Martin J Scanlon; Warren S Alexander; Andrew F Wilks; Peter E Czabotar; Guillaume Lessene; James M Murphy; John Silke
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-06       Impact factor: 11.205

5.  4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.

Authors:  Timothy L Foley; Ganesha Rai; Adam Yasgar; Thomas Daniel; Heather L Baker; Matias Attene-Ramos; Nicolas M Kosa; William Leister; Michael D Burkart; Ajit Jadhav; Anton Simeonov; David J Maloney
Journal:  J Med Chem       Date:  2014-01-22       Impact factor: 7.446

Review 6.  MLKL: Functions beyond serving as the Executioner of Necroptosis.

Authors:  Chaoning Zhan; Minchun Huang; Xiaojun Yang; Jin Hou
Journal:  Theranostics       Date:  2021-03-04       Impact factor: 11.556

7.  Reconstitution of Human Necrosome Interactions in Saccharomyces cerevisiae.

Authors:  Y Ji; L A Ward; C J Hawkins
Journal:  Biomolecules       Date:  2021-01-25

8.  Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.

Authors:  Patricia Dranchak; Ryan MacArthur; Rajarshi Guha; William J Zuercher; David H Drewry; Douglas S Auld; James Inglese
Journal:  PLoS One       Date:  2013-03-07       Impact factor: 3.240
  8 in total

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