Literature DB >> 15990094

Molecular interaction of delta-conotoxins with voltage-gated sodium channels.

Enrico Leipold1, Alfred Hansel, Baldomero M Olivera, Heinrich Terlau, Stefan H Heinemann.   

Abstract

Various neurotoxic peptides modulate voltage-gated sodium (Na(V)) channels and thereby affect cellular excitability. Delta-conotoxins from predatory cone snails slow down inactivation of Na(V) channels, but their interaction site and mechanism of channel modulation are unknown. Here, we show that delta-conotoxin SVIE from Conus striatus interacts with a conserved hydrophobic triad (YFV) in the domain-4 voltage sensor of Na(V) channels. This site overlaps with that of the scorpion alpha-toxin Lqh-2, but not with the alpha-like toxin Lqh-3 site. Delta-SVIE functionally competes with Lqh-2, but exhibits strong cooperativity with Lqh-3, presumably by synergistically trapping the voltage sensor in its "on" position.

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Year:  2005        PMID： 15990094     DOI： 10.1016/j.febslet.2005.05.077

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  33 in total

1.  Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis.

Authors:  Bert Billen; Alexander Vassilevski; Anton Nikolsky; Sarah Debaveye; Jan Tytgat; Eugene Grishin
Journal:  J Biol Chem       Date:  2010-04-12       Impact factor: 5.157

2.  δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.

Authors:  Ai-Hua Jin; Mathilde R Israel; Marco C Inserra; Jennifer J Smith; Richard J Lewis; Paul F Alewood; Irina Vetter; Sébastien Dutertre
Journal:  Proc Biol Sci       Date:  2015-07-22       Impact factor: 5.349

Review 3.  Voltage-gated sodium channel modulation by scorpion alpha-toxins.

Authors:  Frank Bosmans; Jan Tytgat
Journal:  Toxicon       Date:  2006-09-28       Impact factor: 3.033

Review 4.  Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.

Authors:  Frank Bosmans; Jan Tytgat
Journal:  Toxicon       Date:  2006-12-05       Impact factor: 3.033

5.  The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons.

Authors:  Hui Xiang; Wucheng Tao; Lei Wang; Fang Wang; Anlong Xu
Journal:  Cell Mol Neurobiol       Date:  2008-06-26       Impact factor: 5.046

Review 6.  Use of venom peptides to probe ion channel structure and function.

Authors:  Sébastien Dutertre; Richard J Lewis
Journal:  J Biol Chem       Date:  2010-02-26       Impact factor: 5.157

7.  Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels.

Authors:  Joel Z Zhang; Vladimir Yarov-Yarovoy; Todd Scheuer; Izhar Karbat; Lior Cohen; Dalia Gordon; Michael Gurevitz; William A Catterall
Journal:  J Biol Chem       Date:  2011-07-27       Impact factor: 5.157

8.  Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.

Authors:  Maya Gur; Roy Kahn; Izhar Karbat; Noa Regev; Jinti Wang; William A Catterall; Dalia Gordon; Michael Gurevitz
Journal:  J Biol Chem       Date:  2011-08-08       Impact factor: 5.157

9.  Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

Authors:  Michael J Wilson; Min-Min Zhang; Joanna Gajewiak; Layla Azam; Jean E Rivier; Baldomero M Olivera; Doju Yoshikami
Journal:  J Neurophysiol       Date:  2015-01-28       Impact factor: 2.714

Review 10.  The insecticidal potential of venom peptides.

Authors:  Jennifer J Smith; Volker Herzig; Glenn F King; Paul F Alewood
Journal:  Cell Mol Life Sci       Date:  2013-03-23       Impact factor: 9.261
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