PURPOSE: Non-Hodgkin's lymphoma of the breast represents 0.04%-0.50% of malignant lesions of the mammary gland. In this article, we report a single institution's experience with this rare disease. MATERIALS AND METHODS: Between 1982 and 1997, 19 patients with breast lymphoma were diagnosed, treated, and followed at this institution. RESULTS: There were 18 female patients and 1 male patient. All but one were cases of aggressive B-cell lymphoma. Ann Arbor stages were IE (n=5), IIE (n=9), IIIE (n=2), and IV (n=3). International Prognosis Index scores were 0 (n=2), 1 (n=8), 2 (n=7), and 3 (n=2). According to the Wiseman and Liao classification established in 1972, 11 cases were primary lymphomas of the breast, and 8 cases were secondary involvement of the breast. Median survival time was 21.5 months (range, 5.1-114.7 months). The 5-year overall survival was 29%. Median event-free survival time was 8.3 months. The clinical, radiologic, and histologic patterns of presentation match previously published data, even if the response rates and the survival times seem disappointing, probably because of the initial treatment by tumorectomy or mastectomy for some patients. CONCLUSIONS: Systemic chemotherapy should be the mainstay of treatment. Based on our experience and a review of the literature, the use of Wiseman and Liao's classification is questionable. In fact, it fails to detect whether some lymphomas of the breast present a specific natural history and therefore require specific management. New clinical and histologic criteria are to be identified.
PURPOSE:Non-Hodgkin's lymphoma of the breast represents 0.04%-0.50% of malignant lesions of the mammary gland. In this article, we report a single institution's experience with this rare disease. MATERIALS AND METHODS: Between 1982 and 1997, 19 patients with breast lymphoma were diagnosed, treated, and followed at this institution. RESULTS: There were 18 female patients and 1 male patient. All but one were cases of aggressive B-cell lymphoma. Ann Arbor stages were IE (n=5), IIE (n=9), IIIE (n=2), and IV (n=3). International Prognosis Index scores were 0 (n=2), 1 (n=8), 2 (n=7), and 3 (n=2). According to the Wiseman and Liao classification established in 1972, 11 cases were primary lymphomas of the breast, and 8 cases were secondary involvement of the breast. Median survival time was 21.5 months (range, 5.1-114.7 months). The 5-year overall survival was 29%. Median event-free survival time was 8.3 months. The clinical, radiologic, and histologic patterns of presentation match previously published data, even if the response rates and the survival times seem disappointing, probably because of the initial treatment by tumorectomy or mastectomy for some patients. CONCLUSIONS: Systemic chemotherapy should be the mainstay of treatment. Based on our experience and a review of the literature, the use of Wiseman and Liao's classification is questionable. In fact, it fails to detect whether some lymphomas of the breast present a specific natural history and therefore require specific management. New clinical and histologic criteria are to be identified.
Authors: Flora Zagouri; Theodoros N Sergentanis; Afroditi Nonni; Dimitra Koulocheri; Philip Domeyer; Dimitrios Dardamanis; Nikolaos V Michalopoulos; Nikolaos Pararas; Antonia Gounaris; George C Zografos Journal: J Med Case Rep Date: 2007-10-23
Authors: Alvi Chomariyati; Muhammad Noor Diansyah; Putu Niken Ayu Amrita; Pradana Zaky Romadhon; Siprianus Ugroseno Yudho Bintoro; Ami Ashariati; Merlyna Savitri Journal: Ann Med Surg (Lond) Date: 2022-07-31
Authors: Wendy Jeanneret-Sozzi; Alphonse Taghian; Ron Epelbaum; Philip Poortmans; Daniel Zwahlen; Beat Amsler; Sylviane Villette; Yazid Belkacémi; Tan Nguyen; Pierre Scalliet; Philippe Maingon; Cristina Gutiérrez; Pauline Gastelblum; Marco Krengli; Rita Abi Raad; Mahmut Ozsahin; René-Olivier Mirimanoff Journal: BMC Cancer Date: 2008-04-01 Impact factor: 4.430