Literature DB >> 15987189

Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.

Naonobu Tanaka1, Mamoru Okasaka, Youko Ishimaru, Yoshihisa Takaishi, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Uddin Ahmed, L Mark Consentino, Kuo-Hsiung Lee.   

Abstract

[structure: see text] A structurally unique hydrophobic compound, biyouyanagin A, was isolated from the MeOH extract of the leaves of Hypericum chinense L. var. salicifolium. The structure of biyouyanagin A was elucidated on the basis of spectroscopic evidence. Biyouyanagin A showed a significant activity against HIV and inhibited cytokine production.

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Year:  2005        PMID: 15987189      PMCID: PMC2562601          DOI: 10.1021/ol050960w

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  5 in total

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  5 in total
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2.  Total synthesis and structural revision of biyouyanagin B.

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4.  Design, synthesis, and biological evaluation of a biyouyanagin compound library.

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7.  Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof.

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Review 8.  Characteristic metabolites of Hypericum plants: their chemical structures and biological activities.

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9.  Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.

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